Recent Advances of Salivary Gland Biopsy in Sjogren's Syndrome

Liao, Rui1; Yang, Hai-Tao1; Li, Heng2,3; Liu, Li-Xiong2,3; Li, Kai2,3; Li, Jing-Jing2,3; Liang, Jie1; Hong, Xiao-Ping2,3; Chen, Yu-Lan2,3; Liu, Dong-Zhou2,3

2022-01-10

10.3389/fmed.2021.792593

FRONTIERS IN MEDICINE   影响因子和分区

2296-858X

Sjogren's syndrome (SS) is a chronic, systemic, inflammatory autoimmune disease characterized by lymphocyte proliferation and progressive damage to exocrine glands. The diagnosis of SS is challenging due to its complicated clinical manifestations and non-specific signs. Salivary gland biopsy plays an important role in the diagnosis of SS, especially with anti-Sjogren's syndrome antigen A (SSA) and anti-SSB antibody negativity. Histopathology based on biopsy has clinical significance for disease stratification and prognosis evaluation, such as risk assessment for the development of non-Hodgkin's lymphoma. Furthermore, histopathological changes of salivary gland may be implicated in evaluating the efficacy of biological agents in SS. In this review, we summarize the histopathological features of salivary gland, the mechanism of histopathological changes and their clinical significance, as well as non-invasive imaging techniques of salivary glands as a potential alternative to salivary gland biopsy in SS.

Sjogren's syndrome salivary gland biopsy histopathology mechanism clinical significance

SCI

英语

通讯

National Natural Science Foundation of China[81971464] ; National Key Research and Development Program of China[2019YFC0840603]

General & Internal Medicine

Medicine, General & Internal

WOS:000756287800001

FRONTIERS MEDIA SA

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Shenzhen, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China
3.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Rheumatol & Immunol, Jinan, Peoples R China

Liao, Rui,Yang, Hai-Tao,Li, Heng,et al. Recent Advances of Salivary Gland Biopsy in Sjogren's Syndrome[J]. FRONTIERS IN MEDICINE,2022,8.

Liao, Rui.,Yang, Hai-Tao.,Li, Heng.,Liu, Li-Xiong.,Li, Kai.,...&Liu, Dong-Zhou.(2022).Recent Advances of Salivary Gland Biopsy in Sjogren's Syndrome.FRONTIERS IN MEDICINE,8.

Liao, Rui,et al."Recent Advances of Salivary Gland Biopsy in Sjogren's Syndrome".FRONTIERS IN MEDICINE 8(2022).