Multifunctional phototheranostic nanoplatform based on polydopamine-manganese dioxide-IR780 iodide for effective magnetic resonance imaging-guided synergistic photodynamic/photothermal therapy

Mo, Zhimin1; Qiu, Mengjun3; Zhao, Kan1; Hu, Han1; Xu, Qi1; Cao, Jinguo1; Luo, Yuxuan1; Liu, Liping4; Xu, Zushun1; Yi, Changfeng1; Xiong, Zhifan3; Liao, Guangfu5; Yang, Shengli2

2022-04-01

10.1016/j.jcis.2021.12.071

JOURNAL OF COLLOID AND INTERFACE SCIENCE   影响因子和分区

0021-9797

1095-7103

Multifunctional phototheranostics combining diagnostic and therapeutic modalities may provide a revolutionary opportunity for cancer treatment. As a promising tumor phototheranostic molecule, IR780 iodide (IR780) shows excellent photodynamic and photothermal performance under near-infrared laser irradiation; however, its hydrophobicity and instability limit its further use in organisms. This work demonstrates the design and development of a multifunctional nanoplatform (PMIDA, referring to polydopamine (PDA)-manganese dioxide (MnO2)-IR780) for imaging-guided phototherapy. The good biocompatibility of PDA greatly improves the water solubility and photostability of IR780, and its excellent photothermal properties make PMIDA a dual photothermal therapy (PTT). MnO2-induced generation of oxygen in the tumor microenvironment improves the hypoxia effect and photodynamic therapy (PDT) of IR780. Moreover, Mn2+ serves as a decent T-1 -weighted magnetic resonance imaging (MRI) probe to guide treatment. Notably, in relevant cellular assays, PMIDA shows high photodynamic and photothermal effects contributing to the final therapeutic effect. The MRI-guided PDT/PTT synergistic therapy effect in vivo is demonstrated by precise tumor diagnosis and complete tumor elimination outcomes. Based on these experiments, PMIDA nanoparticles display promising effects in facilitating intravenous injection of IR780 and achieving magnetic resonance imaging (MRI)-guided phototheranostic efficacy for tumor treatment. (C) 2021 Elsevier Inc. All rights reserved.

Phototheranostics Stimulus response Synergistic therapy Magnetic resonance imaging (MRI)

SCI ; EI

英语

其他

National Natural Science Foun-dation of China[51573039]

Chemistry

Chemistry, Physical

WOS:000750623600005

ACADEMIC PRESS INC ELSEVIER SCIENCE

CHEMISTRY

Web of Science

1.Hubei Univ, Sch Mat Sci & Engn, Hubei Key Lab Polymer Mat, Minist Educ,Key Lab Green Preparat & Applicat Fun, Wuhan 430062, Hubei, Peoples R China
2.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Ctr Canc, Wuhan 430022, Peoples R China
3.Huazhong Univ Sci & Technol, Liyuan Hosp, Div Gastroenterol, Tongji Med Coll, Wuhan 430077, Peoples R China
4.Southern Univ Sci & Technol, Affiliated Hosp 1, Jinan Univ, Shenzhen Peoples Hosp,Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China
5.China Univ Geosci, Minist Educ, Engn Res Ctr Nanogeomat, Wuhan 430074, Peoples R China

Mo, Zhimin,Qiu, Mengjun,Zhao, Kan,et al. Multifunctional phototheranostic nanoplatform based on polydopamine-manganese dioxide-IR780 iodide for effective magnetic resonance imaging-guided synergistic photodynamic/photothermal therapy[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2022,611.

Mo, Zhimin.,Qiu, Mengjun.,Zhao, Kan.,Hu, Han.,Xu, Qi.,...&Yang, Shengli.(2022).Multifunctional phototheranostic nanoplatform based on polydopamine-manganese dioxide-IR780 iodide for effective magnetic resonance imaging-guided synergistic photodynamic/photothermal therapy.JOURNAL OF COLLOID AND INTERFACE SCIENCE,611.

Mo, Zhimin,et al."Multifunctional phototheranostic nanoplatform based on polydopamine-manganese dioxide-IR780 iodide for effective magnetic resonance imaging-guided synergistic photodynamic/photothermal therapy".JOURNAL OF COLLOID AND INTERFACE SCIENCE 611(2022).