Case Report: IgA Nephropathy in a Patient With Anti-Transcription Intermediary Factor-1 gamma Antibody-Positive Dermatomyositis

Zhang, Suo1,2; Chen, Yu-Lan1; Liu, Cui-Lian1; Xie, Jing-Yi1; Sun, Bao-Dong1; Liu, Dong-Zhou1

2022-02-03

10.3389/fimmu.2022.757802

Frontiers in Immunology   影响因子和分区

1664-3224

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis characterized by IgA deposits in the mesangial area of glomeruli. Connective tissue disorders are some of the most frequent causes of secondary IgAN. Nevertheless, IgAN rarely occurs in systemic autoimmune myopathies (SAMs). The present case study reports on a 58-year-old patient with dermatomyositis with positive anti-transcription intermediary factor (TIF)-1 gamma antibodies who was diagnosed with IgAN during standard immunosuppressive therapy. Moreover, we have made a systematic review regarding the association of SAMs and IgAN. To the best of the authors' knowledge, this is the first case study describing a patient with anti-TIF1 gamma antibody-positive dermatomyositis who developed IgAN, which demonstrates a potential relationship between anti-TIF1 gamma-positive dermatomyositis and IgAN. It is important for clinicians to be aware of the possibility of renal involvement in patients with SAMs, even in those with anti-TIF1 gamma-positive dermatomyositis.

IgA nephropathy systemic autoimmune myopathies dermatomyositis anti- transcription intermediary factor-1 gamma antibody dermatomyositis-specific antibodies

SCI

英语

第一 ; 通讯

Shenzhen Science and Technology Innovation Program[JCYJ20190807144418845] ; National Natural Science Foundation of China[81971464] ; National Key Research and Development Program of China[2019YFC0840603]

Immunology

Immunology

WOS:000760838900001

FRONTIERS MEDIA SA

Web of Science

1.Southern Univ Sci & Technol, Affiliated Hosp 1, Dept Rheumatol & Immunol, Jinan Univ,Clin Med Coll 2,Shenzhen Peoples Hosp, Shenzhen, Peoples R China
2.Shenzhen Second Peoples Hosp, Dept Rheumatol & Immunol, Shenzhen, Peoples R China

Zhang, Suo,Chen, Yu-Lan,Liu, Cui-Lian,et al. Case Report: IgA Nephropathy in a Patient With Anti-Transcription Intermediary Factor-1 gamma Antibody-Positive Dermatomyositis[J]. Frontiers in Immunology,2022,13.

Zhang, Suo,Chen, Yu-Lan,Liu, Cui-Lian,Xie, Jing-Yi,Sun, Bao-Dong,&Liu, Dong-Zhou.(2022).Case Report: IgA Nephropathy in a Patient With Anti-Transcription Intermediary Factor-1 gamma Antibody-Positive Dermatomyositis.Frontiers in Immunology,13.

Zhang, Suo,et al."Case Report: IgA Nephropathy in a Patient With Anti-Transcription Intermediary Factor-1 gamma Antibody-Positive Dermatomyositis".Frontiers in Immunology 13(2022).