南方科技大学知识苑(SUSTech KC): The microRNA-1278/SHP-1/STAT3 pathway is involved in airway smooth muscle cell proliferation in a model of severe asthma both intracellularly and extracellularly

题名	The microRNA-1278/SHP-1/STAT3 pathway is involved in airway smooth muscle cell proliferation in a model of severe asthma both intracellularly and extracellularly
作者	Li, Jie ; Chen, Rongchang; Lu, Yongzhen; Zeng, Yuwei
通讯作者	Li, Jie
发表日期	2022-02-01
DOI	10.1007/s11010-022-04358-8
发表期刊	MOLECULAR AND CELLULAR BIOCHEMISTRY 影响因子和分区
ISSN	0300-8177
EISSN	1573-4919
摘要	This study investigated the regulatory effects of microRNA-1278 (miR-1278) on airway inflammation, airway reconstruction, and the proliferation and apoptosis of airway smooth muscle cells (ASMCs) induced by transforming growth factor beta 1 (TGF-beta 1). The results showed that miR-1278 was upregulated in the blood and lung tissues (LTs) of patients with asthma compared with that in healthy volunteers; miR-1278 expression was also upregulated in asthmatic mice, and miR-1278 inhibition improved the LTs of asthmatic mice. Moreover, miR-1278 inhibited inflammation in asthmatic mice and counteracted the effect of TGF-beta 1 of induced proliferation and reduced apoptosis in ASMCs. DLRA indicated that miR-1278 targeted the 3'-UTR of Src-homology 2-containing phosphatase 1 (SHP-1). Furthermore, miR-1278 promoted ASMC proliferation, in which TGF-beta 1 played an important role by regulating the SHP-1/STAT3 signaling pathway. In conclusion, this study showed that miR-1278 played a critical role in the processes of airway remodeling and reduction of apoptosis by targeting SHP-1.
关键词	Asthma Lung tissue miR-1278 SHP-1 STAT3 ASMC TGF-beta 1
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	NSFC[81770028] ; Key Laboratory of Shenzhen Respiratory Disease[ZDSYS201504301616234] ; Clinical Research of Shenzhen Municipal Health and Family Planning Commission[SZLY2017024]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000756363800001
出版者	SPRINGER
ESI学科分类	MOLECULAR BIOLOGY & GENETICS
来源库	Web of Science
引用统计	被引频次[WOS]：5
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/291040
专题	南方科技大学第一附属医院
作者单位	Jinan Univ, Key Lab Shenzhen Resp Dis,Affiliated Hosp 1, Shenzhen Inst Resp Dis,Shenzhen Peoples Hosp, Southern Univ Sci & Technol,Clin Med Coll 2, 1017 Dongmen North Rd, Shenzhen 518020, Guangdong, Peoples R China
第一作者单位	南方科技大学第一附属医院
通讯作者单位	南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Li, Jie,Chen, Rongchang,Lu, Yongzhen,et al. The microRNA-1278/SHP-1/STAT3 pathway is involved in airway smooth muscle cell proliferation in a model of severe asthma both intracellularly and extracellularly[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY,2022.
APA	Li, Jie,Chen, Rongchang,Lu, Yongzhen,&Zeng, Yuwei.(2022).The microRNA-1278/SHP-1/STAT3 pathway is involved in airway smooth muscle cell proliferation in a model of severe asthma both intracellularly and extracellularly.MOLECULAR AND CELLULAR BIOCHEMISTRY.
MLA	Li, Jie,et al."The microRNA-1278/SHP-1/STAT3 pathway is involved in airway smooth muscle cell proliferation in a model of severe asthma both intracellularly and extracellularly".MOLECULAR AND CELLULAR BIOCHEMISTRY (2022).