A Novel Targeted Nanoparticle for Traumatic Brain Injury Treatment: Combined Effect of ROS Depletion and Calcium Overload Inhibition

Han, Zhengzhong1,2; Han, Yuhan1; Huang, Xuyang1,3; Ma, Hongwei1; Zhang, Xuefeng1; Song, Jingyuan4; Dong, Jun5; Li, Shanshan6,7; Yu, Rutong1,3; Liu, Hongmei1,2

2022-02-01

10.1002/adhm.202102256

Advanced Healthcare Materials   影响因子和分区

2192-2640

2192-2659

Survival after severe traumatic brain injury (TBI) depends on minimizing or avoiding secondary insults to the brain. Overproduction of reactive oxygen species (ROS) and Ca2+ influx at the damaged site are the key factors that cause secondary injury upon TBI. Herein, a TBI-targeted lipid covered radical scavenger nanoparticle is developed to deliver nimodipine (Np) (CL-PPS/Np), in order to inhibit Ca2+ influx in neurons by Np and to scavenge ROS in the brain trauma microenvironment by poly(propylene sulfide)(60) (PPS60) and thus prevent TBI-associated secondary injury. In post-TBI models, CL-PPS/Np effectively accumulates into the wound cavity and prolongs the time of systemic circulation of Np. CL-PPS/Np can markedly protect the integrity of blood-brain barrier, prevent brain edema, reduce cell death and inflammatory responses, and promote functional recovery after TBI. These findings may provide a new therapy for TBI to prevent the spread of the secondary injury.

Ca2+ influx lipid-radical scavenger nanoparticles nimodipine reactive oxygen species targeted drug delivery traumatic brain injury

SCI ; EI

英语

通讯

Social Development Project of Jiangsu Department of Science and Technology[BE2020647] ; Six Talents Peak Foundation of Jiangsu Province[2018-WSW-071] ; Natural Science Foundation of the Jiangsu Higher Education Institutions of China[18KJA320013] ; Social Development Project of Xuzhou Department of Science and Technology[KC20079]

Engineering ; Science & Technology - Other Topics ; Materials Science

Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials

WOS:000756692700001

WILEY

20220811672041

Brain ; Calcium ; Calcium compounds ; Carboxylic acids ; Cell death ; Controlled drug delivery ; Molecular biology ; Oxygen ; Pyridine ; Sulfur compounds ; Synthesis (chemical) ; Targeted drug delivery

Biomedical Engineering:461.1 ; Biology:461.9 ; Alkaline Earth Metals:549.2 ; Nanotechnology:761 ; Chemical Reactions:802.2 ; Chemical Products Generally:804 ; Organic Compounds:804.1 ; Solid State Physics:933

Web of Science

1.Xuzhou Med Univ, Inst Nervous Syst Dis, Xuzhou 221002, Jiangsu, Peoples R China
2.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China
3.Xuzhou Med Univ, Affiliated Hosp, Dept Neurosurg, Xuzhou 221002, Jiangsu, Peoples R China
4.Xuzhou Med Univ, Sch Nursing, Xuzhou 221002, Jiangsu, Peoples R China
5.Suzhou Univ, Affiliated Hosp 2, Dept Neurosurg, Suzhou 215000, Peoples R China
6.Xuzhou Med Univ, Jiangsu Med Engn Res Ctr Gene Detect, Xuzhou 221002, Jiangsu, Peoples R China
7.Xuzhou Med Univ, Dept Forens Med, Xuzhou 221002, Jiangsu, Peoples R China

Han, Zhengzhong,Han, Yuhan,Huang, Xuyang,et al. A Novel Targeted Nanoparticle for Traumatic Brain Injury Treatment: Combined Effect of ROS Depletion and Calcium Overload Inhibition[J]. Advanced Healthcare Materials,2022,11.

Han, Zhengzhong.,Han, Yuhan.,Huang, Xuyang.,Ma, Hongwei.,Zhang, Xuefeng.,...&Liu, Hongmei.(2022).A Novel Targeted Nanoparticle for Traumatic Brain Injury Treatment: Combined Effect of ROS Depletion and Calcium Overload Inhibition.Advanced Healthcare Materials,11.

Han, Zhengzhong,et al."A Novel Targeted Nanoparticle for Traumatic Brain Injury Treatment: Combined Effect of ROS Depletion and Calcium Overload Inhibition".Advanced Healthcare Materials 11(2022).