The Transient IFN Response and the Delay of Adaptive Immunity Feature the Severity of COVID-19

Xu, Gang1; Qi, Furong1; Wang, Haiyan1; Liu, Yu1; Wang, Xin1; Zou, Rongrong2; Yuan, Jing2; Liao, Xuejiao1; Liu, Yang1; Zhang, Shuye3; Zhang, Zheng1,4,5

2022-01-14

10.3389/fimmu.2021.816745

Frontiers in Immunology   影响因子和分区

1664-3224

COVID-19 patients show heterogeneous and dynamic immune features which determine the clinical outcome. Here, we built a single-cell RNA sequencing (scRNA-seq) dataset for dissecting these complicated immune responses through a longitudinal survey of COVID-19 patients with various categories of outcomes. The data reveals a highly fluctuating peripheral immune landscape in severe COVID-19, whereas the one in asymptomatic/mild COVID-19 is relatively steady. Then, the perturbed immune landscape in peripheral blood returned to normal state in those recovered from severe COVID-19. Importantly, the imbalance of the excessively strong innate immune response and delayed adaptive immunity in the early stage of viral infection accelerates the progression of the disease, indicated by a transient strong IFN response and weak T/B-cell specific response. The proportion of abnormal monocytes appeared early and rose further throughout the severe disease. Our data indicate that a dynamic immune landscape is associated with the progression and recovery of severe COVID-19, and have provided multiple immune biomarkers for early warning of severe COVID-19.

COVID-19 ScRNA-seq early immune feature IFN response delayed adaptive immunity

SCI

英语

第一 ; 通讯

Immunology

Immunology

WOS:000758510000001

FRONTIERS MEDIA SA

Web of Science

1.Southern Univ Sci & Technol, Affiliated Hosp 2, Shenzhen Peoples Hosp 3, Inst Hepatol,Natl Clin Res Ctr Infect Dis,Sch Med, Shenzhen AFFILIATED, Peoples R China
2.Shenzhen Third Peoples Hosp, Dept Infect Dis, Shenzhen, Peoples R China
3.Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China
4.Chinese Acad Med Sci, Shenzhen Res Ctr Communicable Dis Diag & Treatmen, Shenzhen, Peoples R China
5.Guangdong Key Lab Antiinfect Drug Qual Evaluat, Shenzhen, Peoples R China

Xu, Gang,Qi, Furong,Wang, Haiyan,et al. The Transient IFN Response and the Delay of Adaptive Immunity Feature the Severity of COVID-19[J]. Frontiers in Immunology,2022,12.

Xu, Gang.,Qi, Furong.,Wang, Haiyan.,Liu, Yu.,Wang, Xin.,...&Zhang, Zheng.(2022).The Transient IFN Response and the Delay of Adaptive Immunity Feature the Severity of COVID-19.Frontiers in Immunology,12.

Xu, Gang,et al."The Transient IFN Response and the Delay of Adaptive Immunity Feature the Severity of COVID-19".Frontiers in Immunology 12(2022).