南方科技大学知识苑(SUSTech KC): PKC delta null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth

题名	PKC delta null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth
作者	Kc, Ranjan 1; Li, Xin 1; Kroin, Jeffrey S.2; Liu, Zhiqiang 1; Chen, Di 1; Xiao, Guozhi 1,3,4 ; Levine, Brett 5; Li, Jinyuan 2; Hamilton, John L.1; van Wijnen, Andre J.6,7; Piel, Margaret 1; Shelly, Daniel A.8; Brass, Dovrat 9; Kolb, Ela 9; Im, Hee-Jeong 1,5,10,11,12
通讯作者	Im, Hee-Jeong
发表日期	2016-12
DOI	10.1136/annrheumdis-2015-208444
发表期刊	ANNALS OF THE RHEUMATIC DISEASES 影响因子和分区
ISSN	0003-4967
EISSN	1468-2060
卷号	75 期号:12页码:2133-2141
摘要	Objectives A key clinical paradox in osteoarthritis (OA), a prevalent age-related joint disorder characterised by cartilage degeneration and debilitating pain, is that the severity of joint pain does not strictly correlate with radiographic and histological defects in joint tissues. Here, we determined whether protein kinase C delta (PKC delta), a key mediator of cartilage degeneration, is critical to the mechanism by which OA develops from an asymptomatic joint-degenerative condition to a painful disease.
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	其他
资助项目	NIH NIAMS[AR053220] ; NIH NIAMS[AR062136] ; NIH NIAMS[AR067935]
WOS研究方向	Rheumatology
WOS类目	Rheumatology
WOS记录号	WOS:000389338900023
出版者	BMJ PUBLISHING GROUP
ESI学科分类	CLINICAL MEDICINE
来源库	Web of Science
引用统计	被引频次[WOS]：40
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/29362
专题	生命科学学院_生物系南方科技大学医学院
作者单位	1.Rush Univ, Med Ctr, Dept Biochem, Chicago, IL 60612 USA 2.Rush Univ, Med Ctr, Dept Anesthesiol, Chicago, IL USA 3.South Univ Sci & Technol China, Dept Biol, Shenzhen, Peoples R China 4.South Univ Sci & Technol China, Shenzhen Key Lab Cell Microenvironm, Shenzhen, Peoples R China 5.Rush Univ, Med Ctr, Dept Orthoped Surg, Chicago, IL 60612 USA 6.Mayo Clin, Dept Orthoped Surg, Rochester, MN USA 7.Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN USA 8.Novozymes Biopharma US, Franklinton, NC USA 9.Alomone Labs Ltd, Jerusalem, Israel 10.Rush Univ, Med Ctr, Dept Internal Med, Sect Rheumatol, Chicago, IL 60612 USA 11.Univ Illinois, Dept Bioengn, Chicago, IL USA 12.Jesse Brown Vet Affairs Med Ctr Chicago, Chicago, IL USA
推荐引用方式 GB/T 7714	Kc, Ranjan,Li, Xin,Kroin, Jeffrey S.,et al. PKC delta null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth[J]. ANNALS OF THE RHEUMATIC DISEASES,2016,75(12):2133-2141.
APA	Kc, Ranjan.,Li, Xin.,Kroin, Jeffrey S..,Liu, Zhiqiang.,Chen, Di.,...&Im, Hee-Jeong.(2016).PKC delta null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth.ANNALS OF THE RHEUMATIC DISEASES,75(12),2133-2141.
MLA	Kc, Ranjan,et al."PKC delta null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth".ANNALS OF THE RHEUMATIC DISEASES 75.12(2016):2133-2141.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可	操作
kc2016.pdf（1982KB）	--	--	限制开放	--