Effect of calcium ions on the nanostiffness of articular cartilage

Pang, Xiangchao1,4,5; Sun, Peng1; Tan, Zhijie4,5; Lin, Lijun2; Tang, Bin1,3

2016-10

10.1016/j.matlet.2016.05.158

MATERIALS LETTERS   影响因子和分区

0167-577X

1873-4979

Calcium is one of the major elements in human body, and critical in the biological and physiological functions. Soft tissue hardening due to calcification has been reported in various diseases. However, the quantitative relationship between the mechanical properties of soft tissues and calcification has not yet been fully understood. In this study, using human articular cartilage as prototype material, the relationship between the ex vivo calcium concentration and the nanostiffness of soft tissues was investigated by indentation-type atomic force microscopy. It is found that the nanostiffness of tissue shows a significant dependence on concentration of calcium ions, when it is higher than the normal serum calcium concentration. Structural observation of collagen fibrils indicated that the increase of nanostiffness should be the result of the increase of crosslinking with the introduction of calcium among collagen molecules. (C) 2016 Elsevier B.V. All rights reserved.

IT-AFM Calcium ions Nano stiffne ss Cros slinking

SCI ; EI

英语

第一 ; 通讯

Shenzhen Science and Technology Innovation Committee[JCYJ20120830154526544] ; Shenzhen Science and Technology Innovation Committee[JCYJ20140612140151890]

Materials Science ; Physics

Materials Science, Multidisciplinary ; Physics, Applied

WOS:000380283000081

ELSEVIER SCIENCE BV

20162402491327

Atomic force microscopy ; Biomechanics ; Biomineralization ; Bone ; Calcium ; Cartilage ; Collagen ; Crosslinking ; Histology ; Ions

Bioengineering and Biology:461 ; Alkaline Earth Metals:549.2 ; Optical Devices and Systems:741.3 ; Chemical Reactions:802.2

MATERIALS SCIENCE

Web of Science

1.South Univ Sci & Technol China, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China
2.Southern Med Univ, Zhujiang Hosp, Dept Orthoped, Guangzhou 510282, Guangdong, Peoples R China
3.Shenzhen Key Lab Nanoimprint Technol, Shenzhen, Peoples R China
4.Wuhan Univ, Sch Phys & Technol, Minist Educ, Dept Phys, Wuhan 430072, Peoples R China
5.Wuhan Univ, Sch Phys & Technol, Minist Educ, Key Lab Artificial Micro & Nanostruct, Wuhan 430072, Peoples R China

Pang, Xiangchao,Sun, Peng,Tan, Zhijie,et al. Effect of calcium ions on the nanostiffness of articular cartilage[J]. MATERIALS LETTERS,2016,180:332-335.

Pang, Xiangchao,Sun, Peng,Tan, Zhijie,Lin, Lijun,&Tang, Bin.(2016).Effect of calcium ions on the nanostiffness of articular cartilage.MATERIALS LETTERS,180,332-335.

Pang, Xiangchao,et al."Effect of calcium ions on the nanostiffness of articular cartilage".MATERIALS LETTERS 180(2016):332-335.