Adenosine A(2B) Receptor: From Cell Biology to Human Diseases

Sun, Ying1,2; Huang, Pingbo3,4,5

2016-08-24

10.3339/fchem.2016.00037

Frontiers in Chemistry   影响因子和分区

2296-2646

Extracellular adenosine is a ubiquitous signaling molecule that modulates a wide array of biological processes. Recently, significant advances have been made in our understanding of A(2B) adenosine receptor (A(2B)AR). In this review, we first summarize some of the general characteristics of A(2B)AR, and then we describe the multiple binding partners of the receptor, such as newly identified alpha-actinin-1 and p105, and discuss how these associated proteins could modulate A(2B)AR's functions, including certain seemingly paradoxical functions of the receptor. Growing evidence indicates a critical role of A(2B)AR in cancer, renal disease, and diabetes, in addition to its importance in the regulation of vascular diseases, and lung disease. Here, we also discuss the role of A(2B)AR in cancer, renal disease, and diabetes and the potential of the receptor as a target for treating these three diseases.

A(2B) adenosine receptor binding proteins cancer renal disease diabetes

SCI

英语

第一 ; 通讯

Hong Kong Research Grants Council grants[GRF660913] ; Hong Kong Research Grants Council grants[GRF16102415]

Chemistry

Chemistry, Multidisciplinary

WOS:000381796200001

FRONTIERS MEDIA SA

Web of Science

1.South Univ Sci & Technol China, Dept Biol, Shenzhen, Peoples R China
2.South Univ Sci & Technol China, Shenzhen Key Lab Cell Microenvironm, Shenzhen, Peoples R China
3.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
4.Hong Kong Univ Sci & Technol, Div Biomed Engn, Hong Kong, Hong Kong, Peoples R China
5.Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Hong Kong, Hong Kong, Peoples R China

Sun, Ying,Huang, Pingbo. Adenosine A(2B) Receptor: From Cell Biology to Human Diseases[J]. Frontiers in Chemistry,2016,4.

Sun, Ying,&Huang, Pingbo.(2016).Adenosine A(2B) Receptor: From Cell Biology to Human Diseases.Frontiers in Chemistry,4.

Sun, Ying,et al."Adenosine A(2B) Receptor: From Cell Biology to Human Diseases".Frontiers in Chemistry 4(2016).