Helical Nonfouling Polypeptides for Biomedical Applications

Zhang, Chong1; Lu, Hua2

2022-03-01

10.1007/s10118-022-2688-2

CHINESE JOURNAL OF POLYMER SCIENCE   影响因子和分区

0256-7679

1439-6203

Synthetic polypeptides, also known as poly(alpha-amino acid)s (P alpha AAs), are biomimetic and biodegradable polymers holding great potential for a variety of biomedical applications. Possessing the same peptide bonds as natural proteins, polypeptides can also adopt typical well-defined secondary structures including alpha-helix, which have been shown to significantly impact the physicochemical properties and biological outcomes of materials. In this feature article, we review the state-of-the-art progresses of alpha-helical polypeptides for biomedical applications, with a special emphasis on the manipulation of helix-to-coil dynamic transition, conformation-associated anti-biofouling coatings, cellular uptake regulation, and reducing immunogenicity of polypeptide-protein conjugates. Finally, perspectives on outstanding challenges remained in this field and some important future directions are discussed.

Poly(alpha-amino acid) Polypeptide Helix Nonfouling PEPylation

SCI ; EI

英语

第一

National Key Research and Development Program of China[2019YFA0904203] ; National Natural Science Fund for Distinguished Young Scholars[22125101]

Polymer Science

Polymer Science

WOS:000765653300001

SPRINGER

20221011759537

Biodegradable polymers ; Functional polymers ; Medical applications ; Molecular biology ; Physicochemical properties ; Proteins

Biology:461.9 ; Physical Chemistry:801.4 ; Organic Compounds:804.1 ; Polymeric Materials:815.1

CHEMISTRY

Web of Science

1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, Ctr Soft Matter Sci & Engn,Minist Educ, Key Lab Polymer Chem & Phys,Beijing Natl Lab Mol, Beijing 100871, Peoples R China

Zhang, Chong,Lu, Hua. Helical Nonfouling Polypeptides for Biomedical Applications[J]. CHINESE JOURNAL OF POLYMER SCIENCE,2022,40:433-446.

Zhang, Chong,&Lu, Hua.(2022).Helical Nonfouling Polypeptides for Biomedical Applications.CHINESE JOURNAL OF POLYMER SCIENCE,40,433-446.

Zhang, Chong,et al."Helical Nonfouling Polypeptides for Biomedical Applications".CHINESE JOURNAL OF POLYMER SCIENCE 40(2022):433-446.