Nano-Hydroxyapatite Bone Scaffolds with Different Porous Structures Processed by Digital Light Processing 3D Printing

Liang, Haowen1,2; Wang, Yue1,3; Chen, Shangsi3; Liu, Yang4; Liu, Zhengbai2; Bai, Jiaming1

2022

10.18063/ijb.v8i1.502

International Journal of Bioprinting   影响因子和分区

2424-7723

2424-8002

The morphologies and structures of the scaffold have a significant influence on their mechanical and biological properties. In this work, different types of porous structures: Triply periodic minimal surface-Schwarz primitive (P), body-centered cubic, and cubic pore-shaped (CPS) hydroxyapatite scaffolds with similar to 70% porosity were fabricated through digital light processing (DLP) 3D printing technology. The compressive properties and in vitro cell evaluations such as cell proliferation and attachment morphology of these scaffolds were systematically compared. The results showed that the CPS scaffolds exhibited the highest compressive strength (similar to 22.5 MPa) and modulus (similar to 400 MPa). In addition, the CPS scaffolds also performed the most active cell metabolisms as compared to other two structures, which may account for the larger pore size and smaller curvature of the substrate. This study provides a general guidance for the fabrication and selection of porous bone scaffolds processed by DLP 3D printing.

Nano-hydroxyapatite Digital light processing Bone scaffolds 3D printing

SCI

英语

第一 ; 通讯

Shenzhen Science and Technology Innovation Commission[KQTD20190929172505711] ; Shenzhen Science and Technology International Cooperation program[GJHZ20200731095606021] ; Shenzhen Science and Technology Program[KQTD2017032815444316] ; Guangdong Province International Collaboration Program[2019A050510003]

Engineering ; Materials Science

Engineering, Biomedical ; Materials Science, Biomaterials

WOS:000767026900002

WHIOCE PUBLISHING PTE LTD, SINGAPORE

Web of Science

1.Southern Univ Sci & Technol, Shenzhen Key Lab Addit Mfg High Performance Mat, Dept Mech & Energy Engn, Shenzhen, Peoples R China
2.Southern Univ Sci & Technol, Sch Innovat & Entrepreneurship, Shenzhen, Peoples R China
3.Univ Hong Kong, Dept Mech Engn, Hong Kong, Peoples R China
4.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen, Peoples R China

Liang, Haowen,Wang, Yue,Chen, Shangsi,et al. Nano-Hydroxyapatite Bone Scaffolds with Different Porous Structures Processed by Digital Light Processing 3D Printing[J]. International Journal of Bioprinting,2022,8(1).

Liang, Haowen,Wang, Yue,Chen, Shangsi,Liu, Yang,Liu, Zhengbai,&Bai, Jiaming.(2022).Nano-Hydroxyapatite Bone Scaffolds with Different Porous Structures Processed by Digital Light Processing 3D Printing.International Journal of Bioprinting,8(1).

Liang, Haowen,et al."Nano-Hydroxyapatite Bone Scaffolds with Different Porous Structures Processed by Digital Light Processing 3D Printing".International Journal of Bioprinting 8.1(2022).