| 题名 | Integration of Count Difference and Curve Similarity in Negative Regulatory Element Detection |
| 作者 | |
| 通讯作者 | He, Na; Hou, Chunhui |
| 发表日期 | 2022-02-18
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| DOI | |
| 发表期刊 | |
| EISSN | 1664-8021
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| 卷号 | 13 |
| 摘要 | Negative regulatory elements (NREs) down-regulate gene expression by inhibiting the activities of promoters or enhancers. The repressing activity of NREs can be measured globally by massively parallel reporter assays (MPRAs). However, most existing algorithms are designed for the statistical detection of positively enriched signals in MPRA datasets. To identify reduced signals in MPRA experiments, we designed a NRE identification program, fast-NR, by integrating the count and graphic features of sequenced reads to detect NREs using datasets generated by experiments of self-transcribing active regulatory region sequencing (STARR-seq). Fast-NR identified hundreds of silencers in human K562 cells that can be validated by independent methods. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 通讯
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| 资助项目 | National Key R&D Program of China[2018YFC1004500]
; Shenzhen Science and Technology Innovation Commission[20200925153547003]
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| WOS研究方向 | Genetics & Heredity
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| WOS类目 | Genetics & Heredity
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| WOS记录号 | WOS:000767526700001
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| 出版者 | |
| 来源库 | Web of Science
|
| 引用统计 |
被引频次[WOS]：1
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/296938 |
| 专题 | 生命科学学院_生物系 生命科学学院 |
| 作者单位 | 1.Harbin Inst Technol, Harbin, Peoples R China 2.Southern Univ Sci & Technol, Sch Life Sci, Dept Biol, Shenzhen, Peoples R China 3.Chinese Univ Hong Kong, Sch Life Sci, Hong Kong, Peoples R China 4.Chinese Univ Hong Kong, State Key Lab Agrobiotechnol, Hong Kong, Peoples R China 5.Univ Macau, Ctr Canc, Fac Hlth Sci, Macau, Peoples R China 6.Huazhong Agr Univ, Dept Bioinformat, Wuhan, Peoples R China 7.Huazhong Agr Univ, Hubei Key Lab Agr Bioinformat, Wuhan, Peoples R China |
| 第一作者单位 | 生物系; 生命科学学院 |
| 通讯作者单位 | 生物系; 生命科学学院 |
| 推荐引用方式 GB/T 7714 |
He, Na,Wang, Wenjing,Fang, Chao,et al. Integration of Count Difference and Curve Similarity in Negative Regulatory Element Detection[J]. FRONTIERS IN GENETICS,2022,13.
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| APA |
He, Na,Wang, Wenjing,Fang, Chao,Tan, Yongjian,Li, Li,&Hou, Chunhui.(2022).Integration of Count Difference and Curve Similarity in Negative Regulatory Element Detection.FRONTIERS IN GENETICS,13.
|
| MLA |
He, Na,et al."Integration of Count Difference and Curve Similarity in Negative Regulatory Element Detection".FRONTIERS IN GENETICS 13(2022).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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