The Multiscale Dynamics of Beat-to-Beat Blood Pressure Fluctuation Links to Functions in Older Adults

Jiang, Xin1,2,3; Cai, Yurun4; Wu, Xiaoyan1,2; Huang, Baofeng1,2,3; Chen, Yurong1; Zhong, Lilian1,2,3; Gao, Xia1,2,3; Guo, Yi2,3,5,6; Zhou, Junhong7,8,9

2022-02-23

10.3389/fcvm.2022.833125

Frontiers in Cardiovascular Medicine   影响因子和分区

2297-055X

BackgroundThe blood pressure (BP) is regulated by multiple neurophysiologic elements over multiple temporal scales. The multiscale dynamics of continuous beat-to-beat BP series, which can be characterized by "BP complexity", may, thus, capture the subtle changes of those elements, and be associated with the level of functional status in older adults. We aimed to characterize the relationships between BP complexity and several important functions in older adults and to understand the underlying factors contributing to BP complexity. MethodA total of 400 older adults completed a series of clinical and functional assessments, a finger BP assessment of at least 10 min, and blood sample and vessel function tests. Their hypertensive characteristics, cognitive function, mobility, functional independence, blood composition, arterial stiffness, and endothelial function were assessed. The complexity of systolic (SBP) and diastolic (DBP) BP series was measured using multiscale entropy. ResultsWe observed that lower SBP and DBP complexity was significantly associated with poorer functional independence (beta > 0.17, p < 0.005), cognitive function (beta > 0.45, p = 0.01), and diminished mobility (beta < -0.57, p < 0.003). Greater arterial stiffness (beta < -0.48, p = 0.02), decreased endothelial function (beta > 0.42, p < 0.03), and excessed level of blood lipids (p < 0.03) were the main contributors to BP complexity. ConclusionBlood pressure complexity is closely associated with the level of multiple functional statuses and cardiovascular health in older adults with and without hypertension, providing novel insights into the physiology underlying BP regulation. The findings suggest that this BP complexity metric would serve as a novel marker to help characterize and manage the functionalities in older adults.

beat-to-beat blood pressure fluctuation multiscale entropy functional independence vessel function blood lipids

SCI ; SSCI

英语

通讯

Sustainable Development Science and Technology Project of Shenzhen Science and Technology Innovation Commission["KCXFZ20201221173411032","KCXFZ20201221173400001"] ; Shenzhen Science and Technology planning project[JCYJ20190807145209306] ; Natural Science Foundation of Guangdong Province[2021A1515010983] ; Shenzhen Key Medical Discipline Construction Fund["SZXK012","SZXK005"]

Cardiovascular System & Cardiology

Cardiac & Cardiovascular Systems

WOS:000766543300001

FRONTIERS MEDIA SA

Web of Science

1.Shenzhen Peoples Hosp, Dept Geriatr, Shenzhen, Peoples R China
2.Jinan Univ, Clin Med Coll 2, Shenzhen, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China
4.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
5.Shenzhen Peoples Hosp, Dept Neurol, Shenzhen, Peoples R China
6.Shenzhen Bay Lab, Shenzhen, Peoples R China
7.Hinda & Arthur Marcus Inst Aging Res, Hebrew SeniorLife, Roslindale, MA USA
8.Beth Israel Deaconess Med Ctr, Div Gerontol, Boston, MA 02215 USA
9.Harvard Med Sch, Boston, MA 02115 USA

Jiang, Xin,Cai, Yurun,Wu, Xiaoyan,et al. The Multiscale Dynamics of Beat-to-Beat Blood Pressure Fluctuation Links to Functions in Older Adults[J]. Frontiers in Cardiovascular Medicine,2022,9.

Jiang, Xin.,Cai, Yurun.,Wu, Xiaoyan.,Huang, Baofeng.,Chen, Yurong.,...&Zhou, Junhong.(2022).The Multiscale Dynamics of Beat-to-Beat Blood Pressure Fluctuation Links to Functions in Older Adults.Frontiers in Cardiovascular Medicine,9.

Jiang, Xin,et al."The Multiscale Dynamics of Beat-to-Beat Blood Pressure Fluctuation Links to Functions in Older Adults".Frontiers in Cardiovascular Medicine 9(2022).