Dacarbazine-Loaded Targeted Polymeric Nanoparticles for Enhancing Malignant Melanoma Therapy

Xiong, Wei1; Guo, Zhengdong1; Zeng, Baoyan1; Wang, Teng2; Zeng, Xiaowei2; Cao, Wei2; Lian, Daizheng3

2022-02-17

10.3389/fbioe.2022.847901

Frontiers in Bioengineering and Biotechnology   影响因子和分区

2296-4185

Dacarbazine (DTIC) dominates chemotherapy for malignant melanoma (MM). However, the hydrophobicity, photosensitivity, instability, and toxicity to normal cells of DTIC limit its efficacy in treating MM. In the present study, we constructed star-shaped block polymers nanoparticles (NPs) based on Cholic acid -poly (lactide-co-glycolide)-b-polyethylene glycol (CA-PLGA-b-PEG) for DTIC encapsulation and MM targeted therapy. DTIC-loaded CA-PLGA-b-PEG NPs (DTIC-NPs) were employed to increase the drug loading and achieve control release of DTIC, followed by further modification with nucleic acid aptamer AS1411 (DTIC-NPs-Apt), which played an important role for active targeted therapy of MM. In vitro, DTIC-NPs-Apt showed good pH-responsive release and the strongest cytotoxicity to A875 cells compared with DTIC-NPs and free DTIC. In vivo results demonstrated that the versatile DTIC-NPs-Apt can actively target the site of MM and exhibited excellent anti-tumor effects with no obvious side effects. Overall, this research provided multi-functional NPs, which endow a new option for the treatment of MM.

cancer nanocarriers targeted drug delivery controlled release copolymer malignant melanoma

SCI ; EI

英语

其他

Science, Technology & Innovation Commission of Shenzhen Municipality[JCYJ20160429182415013]

Biotechnology & Applied Microbiology ; Science & Technology - Other Topics

Biotechnology & Applied Microbiology ; Multidisciplinary Sciences

WOS:000766865200001

FRONTIERS MEDIA SA

Web of Science

1.Huazhong Univ Sci & Technol, Union Shenzhen Hosp, Dept Plast & Burn Surg, Shenzhen, Peoples R China
2.Tsinghua Univ, Grad Sch Shenzhen, Shenzhen, Peoples R China
3.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Radiat Oncol,Jinan Univ,Affiliated Hosp 1, Shenzhen, Peoples R China

Xiong, Wei,Guo, Zhengdong,Zeng, Baoyan,et al. Dacarbazine-Loaded Targeted Polymeric Nanoparticles for Enhancing Malignant Melanoma Therapy[J]. Frontiers in Bioengineering and Biotechnology,2022,10.

Xiong, Wei.,Guo, Zhengdong.,Zeng, Baoyan.,Wang, Teng.,Zeng, Xiaowei.,...&Lian, Daizheng.(2022).Dacarbazine-Loaded Targeted Polymeric Nanoparticles for Enhancing Malignant Melanoma Therapy.Frontiers in Bioengineering and Biotechnology,10.

Xiong, Wei,et al."Dacarbazine-Loaded Targeted Polymeric Nanoparticles for Enhancing Malignant Melanoma Therapy".Frontiers in Bioengineering and Biotechnology 10(2022).