pH-Sensitive and Charge-Reversal Polymeric Nanoplatform Enhanced Photothermal/Photodynamic Synergistic Therapy for Breast Cancer

Wang, Wenyan1; Li, Zimu1; Nie, Xiaozhong2; Zeng, Wenfeng1; Zhang, Yi1; Deng, Yimin1; Chen, Hongzhong1; Zeng, Xiaowei1; Ma, Hualin3; Zheng, Yi4; Gao, Nansha1

2022-02-18

10.3389/fbioe.2022.836468

Frontiers in Bioengineering and Biotechnology   影响因子和分区

2296-4185

As reported, breast cancer is one of the most common malignancies in women and has overtaken lung cancer as the most commonly diagnosed cancer worldwide by 2020. Currently, phototherapy is a promising anti-tumor therapy due to its fewer side effects, less invasiveness, and lower cost. However, its application in cancer therapeutics is limited by the incomplete therapeutic effect caused by low drug penetration and monotherapy. Herein, we built a charge-reversal nanoplatform (Ce6-PLGA@PDA-PAH-DMMA NPs), including polydopamine (PDA) and chlorin e6 (Ce6) for enhancing photothermal/photodynamic synergistic therapy. The PAH-DMMA charge-reversal layer enabled Ce6-PLGA@PDA-PAH-DMMA NPs to have long blood circulation at the normal physiological environment and to successfully realize charge reversal under the weakly acidic tumor microenvironment, improving cellular uptake. Besides, in vitro tests demonstrated that Ce6-PLGA@PDA-PAH-DMMA NPs had high photothermal conversion and greater anti-tumor activity than no charge-reversal nanoparticles, which overcame the limited tumor therapeutic efficacy of PTT or photodynamic therapy alone. Overall, the design of pH-responsive and charge-reversal nanoparticles (Ce6-PLGA@PDA-PAH-DMMA NPs) provided a promising approach for synergistic PTT/PDT therapy against breast cancer.

cancer nanotechnology charge-reversal photodynamic therapy photothermal therapy pH-sensitive

SCI ; EI

英语

通讯

Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties[SZGSP001] ; Shenzhen Key Laboratory of Kidney Diseases[ZDSYS201504301616234] ; Science, Technology and Innovation Commission of Shenzhen Municipality["2021A18","JCYJ20180301170030277"] ; Key Project of Guangzhou Municipal Science and Technology Bureau[201903010039] ; Natural Science Foundation of Guangdong Province[2020A1515011353] ; Science and Technology Innovation Strategic Foundation of Guangdong Province[pdjh 2020b1180] ; Shenzhen Educational Science Planning Project[zdfz20019] ; Guangming District Economic Development Special Fund["2020R01072","2021R01120"]

Biotechnology & Applied Microbiology ; Science & Technology - Other Topics

Biotechnology & Applied Microbiology ; Multidisciplinary Sciences

WOS:000766588800001

FRONTIERS MEDIA SA

Web of Science

1.Sun Yat Sen Univ, Inst Pharmaceut, Sch Pharmaceut Sci, Shenzhen, Peoples R China
2.Shenzhen Polytech, Sch Food & Drug, Shenzhen, Peoples R China
3.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1,Shenzhen Peoples Hosp,Dept Neph, Clin Med Coll 2,Shenzhen Key Lab Kindey Dis, Shenzhen, Peoples R China
4.Univ Chinese Acad Sci, Shenzhen Hosp, Cent Lab, Shenzhen, Peoples R China

Wang, Wenyan,Li, Zimu,Nie, Xiaozhong,et al. pH-Sensitive and Charge-Reversal Polymeric Nanoplatform Enhanced Photothermal/Photodynamic Synergistic Therapy for Breast Cancer[J]. Frontiers in Bioengineering and Biotechnology,2022,10.

Wang, Wenyan.,Li, Zimu.,Nie, Xiaozhong.,Zeng, Wenfeng.,Zhang, Yi.,...&Gao, Nansha.(2022).pH-Sensitive and Charge-Reversal Polymeric Nanoplatform Enhanced Photothermal/Photodynamic Synergistic Therapy for Breast Cancer.Frontiers in Bioengineering and Biotechnology,10.

Wang, Wenyan,et al."pH-Sensitive and Charge-Reversal Polymeric Nanoplatform Enhanced Photothermal/Photodynamic Synergistic Therapy for Breast Cancer".Frontiers in Bioengineering and Biotechnology 10(2022).