Biomimetic Mineralized Hierarchical Graphene Oxide/Chitosan Scaffolds with Adsorbability for Immobilization of Nanoparticles for Biomedical Applications

Xie, Chaoming1; Lu, Xiong1,2; Han, Lu1; Xu, Jielong1; Wang, Zhenming1; Jiang, Lili1; Wang, Kefeng2; Zhang, Hongping3; Ren, Fuzeng4; Tang, Youhong5

2016-01-27

10.1021/acsami.5b09232

ACS Applied Materials & Interfaces   影响因子和分区

1944-8244

Biomimetic calcium phosphate mineralized graphene oxide/chitosan (GO/CS) scaffolds with hierarchical structures were developed. First, GO/CS scaffolds with large micropores (similar to 300 mu m) showed high mechanical strength due to the electrostatic interaction between the oxygen-containing functional groups of GO and the amine groups of CS. Second, GO/CS scaffold octacalcuim phosphate (OCP) with porous structures (similar to 1 mu m) was biomimetically mineralized on the surfaces of the GO/CS scaffolds (OCP-GO/CS). The hierarchical microporous structures of OCP-GO/CS scaffolds provide a suitable environment for cell adhesion and growth. The scaffolds have exceptional adsorbability of nanoparticles. Bone morphogenetic protein-2 (BMP-2)-encapsulated bovine serum albumin (BSA) nanoparticles and Ag nanoparticles (Ag-NPs) were adsorbed in the scaffolds for enhancement of osteoinductivity and antibacterial properties, respectively. Antibacterial tests showed that the scaffolds exhibited high antibacterial properties against both Escherichia coli and Staphylococcus epidermidis. In vitro and in vivo experiments revealed that the scaffolds have good biocompatibility, enhanced bone marrow stromal cells proliferation and differentiation, and induced bone tissue regeneration. Thus, the biomimetic OCP-GO/CS scaffolds with immobilized growth factors and antibacterial agents might be excellent candidates for bone tissue engineering.

graphene oxide biomimetic scaffold hierarchical structure adsorbability osteoinductivity antibacterial property

SCI ; EI

英语

其他

Special Funds for Fundamental Research of Strategic Emerging Industries of Shenzhen[JCYJ20150331101823688]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000369044100021

AMER CHEMICAL SOC

20160501875523

Biocompatibility ; Biomimetics ; Body fluids ; Bone ; Calcium phosphate ; Cell adhesion ; Escherichia coli ; Graphene ; Graphene oxide ; Medical applications ; Microporosity ; Silver nanoparticles ; Tissue ; Tissue regeneration

Bioengineering and Biology:461 ; Nanotechnology:761 ; Chemical Products Generally:804 ; Inorganic Compounds:804.2 ; Physical Properties of Gases, Liquids and Solids:931.2

Web of Science

1.Southwest Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu 610031, Sichuan, Peoples R China
2.Sichuan Univ, Genome Res Ctr Biomat, Natl Engn Res Ctr Biomat, Chengdu 610064, Sichuan, Peoples R China
3.Southwest Univ Sci & Technol, Sch Mat Sci & Engn, Mianyang 621000, Sichuan, Peoples R China
4.South Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China
5.Flinders Univ S Australia, Sch Comp Sci Engn & Math, Ctr NanoScale Sci & Technol, Tonsley, SA 5042, Australia

Xie, Chaoming,Lu, Xiong,Han, Lu,et al. Biomimetic Mineralized Hierarchical Graphene Oxide/Chitosan Scaffolds with Adsorbability for Immobilization of Nanoparticles for Biomedical Applications[J]. ACS Applied Materials & Interfaces,2016,8(3):1707-1717.

Xie, Chaoming.,Lu, Xiong.,Han, Lu.,Xu, Jielong.,Wang, Zhenming.,...&Tang, Youhong.(2016).Biomimetic Mineralized Hierarchical Graphene Oxide/Chitosan Scaffolds with Adsorbability for Immobilization of Nanoparticles for Biomedical Applications.ACS Applied Materials & Interfaces,8(3),1707-1717.

Xie, Chaoming,et al."Biomimetic Mineralized Hierarchical Graphene Oxide/Chitosan Scaffolds with Adsorbability for Immobilization of Nanoparticles for Biomedical Applications".ACS Applied Materials & Interfaces 8.3(2016):1707-1717.