Double-crosslinked bifunctional hydrogels with encapsulated anti-cancer drug for bone tumor cell ablation and bone tissue regeneration

Chen，Shangsi1; Wang，Yue1,2; Zhang，Xin3; Ma，Jun3; Wang，Min1

2022-05-01

10.1016/j.colsurfb.2022.112364

COLLOIDS AND SURFACES B-BIOINTERFACES   影响因子和分区

0927-7765

1873-4367

Many biomaterials are made and studied to provide anticancer therapy, and many other biomaterials have been developed to assist body tissue regeneration. It has been a challenge to design and produce effective multifunctional, or bifunctional, biomaterials for clinical applications to prevent cancer recurrence and, at the same time, to promote new tissue formation after surgical removal of the tumor for millions of cancer patients. In this study, bifunctional UV and Sr double-crosslinked alginate (ALG)/allylated gelatin (GelAGE) hydrogels incorporated with polydopamine (PDA) particles were designed and made. Furthermore, doxorubicin hydrochloride (DOX), an anticancer drug, was incorporated in PDA particles. It was aimed for the new ALG/GelAGE-PDA@DOX hydrogels to exhibit anticancer synergy and hence provide combined chemotherapy and phototherapy (PTT) for bone tumor cell ablation. In vitro experiments using MG63 osteosarcoma cells showed that ALG/GelAGE-PDA@DOX hydrogels could effectively kill tumor cells through the synergy of controlled DOX release and hyperthermia ablation. It was also aimed for the new hydrogels to facilitate bone tissue regeneration at the original bone tumor site. The results of in vitro experiments demonstrated that owing to the release of Sr, the new hydrogels could promote the proliferation of rat bone mesenchymal stem cells (rBMSCs) and also the alkaline phosphatase (ALP) activity of cells, indicating their osteogenic promotion ability. The ALG/GelAGE-PDA@DOX hydrogels have therefore exhibited great potential for the treatment of bone tumor-related defects.

Anti-tumor effect Bone regeneration Drug delivery Hydrogel Polydopamine

SCI ; EI

英语

其他

Hong Kong's Research Grants Council (RGC) through GRF[17201017,17200519,17202921]

Biophysics ; Chemistry ; Materials Science

Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials

WOS:000797733500002

ELSEVIER

20220911739759

Ablation ; Bone ; Cell culture ; Chemotherapy ; Controlled drug delivery ; Crosslinking ; Diseases ; Phosphatases ; Stem cells ; Targeted drug delivery ; Tissue regeneration ; Tumors

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Heat Transfer:641.2 ; Colloid Chemistry:801.3 ; Chemical Reactions:802.2 ; Chemical Products Generally:804

BIOLOGY & BIOCHEMISTRY

2-s2.0-85125507817

Scopus

1.Department of Mechanical Engineering,The University of Hong Kong,Pokfulam Road,Hong Kong
2.Department of Mechanical and Energy Engineering,Southern University of Science and Technology,Shenzhen,518055,China
3.Advanced Biomaterials and Tissue Engineering Center,Huazhong University of Science and Technology,Wuhan,430074,China

Chen，Shangsi,Wang，Yue,Zhang，Xin,et al. Double-crosslinked bifunctional hydrogels with encapsulated anti-cancer drug for bone tumor cell ablation and bone tissue regeneration[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2022,213.

Chen，Shangsi,Wang，Yue,Zhang，Xin,Ma，Jun,&Wang，Min.(2022).Double-crosslinked bifunctional hydrogels with encapsulated anti-cancer drug for bone tumor cell ablation and bone tissue regeneration.COLLOIDS AND SURFACES B-BIOINTERFACES,213.

Chen，Shangsi,et al."Double-crosslinked bifunctional hydrogels with encapsulated anti-cancer drug for bone tumor cell ablation and bone tissue regeneration".COLLOIDS AND SURFACES B-BIOINTERFACES 213(2022).