Auditory nerve impulses induced by 980 nm laser

Guan, Tian1; Zhu, Kai1,2; Chen, Fei3; He, Yonghong4; Wang, Jian5; Wu, Mocun1,2; Nie, Guohui6

2015-08

10.1117/1.JBO.20.8.088004

JOURNAL OF BIOMEDICAL OPTICS   影响因子和分区

1083-3668

1560-2281

The discovery that a pulsed laser could trigger an auditory neural response inspired ongoing research on cochlear implants activated by optical stimulus rather than by electrical current. However, most studies to date have used visible light (532 nm) or long-wavelength near-infrared (>1840 nm) and involved making a hole in the cochlea. This paper investigates the effect of optical parameters on the optically evoked compound action potentials (oCAPs) from the guinea pig cochlea, using a pulsed semiconductor near-infrared laser (980 nm) without making a hole in the cochlea. Synchronous trigger laser pulses were used to stimulate the cochlea, before and after deafening, upon varying the pulse duration (30-1000 mu s) and an amount of radiant energy (0-53.2 mJ/cm(2)). oCAPs were successfully recorded after deafening. The amplitude of the oCAPs increased as the infrared radiant energy was increased at a fixed 50 mu s pulse duration, and decreased with a longer pulse duration at a fixed 37.1 mJ/cm(2) radiant energy. The latency of the oCAPs shortened with increasing radiant energy at a fixed pulse duration. With a higher stimulation rate, the amplitude of the oCAPs' amplitude decreased. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.

near-infrared laser cochlear implant optical stimulation optically evoked compound action potentials

SCI ; EI

英语

其他

Nature Science Foundation of China[NSFC81401539] ; Nature Science Foundation of China[NSFC31271056]

Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging

Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging

WOS:000362516700029

SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS

20153501222063

Cochlear implants ; Electrophysiology ; Infrared devices ; Infrared lasers ; Mammals ; Semiconductor lasers

Biomedical Engineering:461.1 ; Prosthetics:462.4 ; Lasers, General:744.1 ; Semiconductor Lasers:744.4.1

CLINICAL MEDICINE

Web of Science

1.Tsinghua Univ, Grad Sch Shenzhen, Biomed Engn Res Ctr, Shenzhen 518055, Guangdong, Peoples R China
2.Tsinghua Univ, Sch Med, Dept Biomed Engn, Beijing 100084, Peoples R China
3.South Univ Sci & Technol China, Dept Elect & Elect Engn, Shenzhen 518055, Guangdong, Peoples R China
4.Tsinghua Univ, Grad Sch Shenzhen, Lab Opt Imaging & Sensing, Shenzhen 518055, Guangdong, Peoples R China
5.Shenzhen Inst Informat Technol, Sch Elect & Commun, Shenzhen 518172, Guangdong, Peoples R China
6.Peking Univ, Shenzhen Hosp, Dept Otolaryngol, Shenzhen 518036, Guangdong, Peoples R China

Guan, Tian,Zhu, Kai,Chen, Fei,et al. Auditory nerve impulses induced by 980 nm laser[J]. JOURNAL OF BIOMEDICAL OPTICS,2015,20(8).

Guan, Tian.,Zhu, Kai.,Chen, Fei.,He, Yonghong.,Wang, Jian.,...&Nie, Guohui.(2015).Auditory nerve impulses induced by 980 nm laser.JOURNAL OF BIOMEDICAL OPTICS,20(8).

Guan, Tian,et al."Auditory nerve impulses induced by 980 nm laser".JOURNAL OF BIOMEDICAL OPTICS 20.8(2015).