南方科技大学知识苑(SUSTech KC): Pulsed infrared stimulation evoked electrical potential in mouse vestibular system

题名	Pulsed infrared stimulation evoked electrical potential in mouse vestibular system
作者	Jiang，Weitao1 ; Wang，Zihan 2; Xiao，Shijie1 ; Zeng，Dingxuan 1; Wu，Zhuli1 ; Peng，Cheng1,3 ; Chen，Fangyi1,4,5
通讯作者	Peng，Cheng; Chen，Fangyi
发表日期	2022-04-01
DOI	10.1016/j.neulet.2022.136510
发表期刊	NEUROSCIENCE LETTERS 影响因子和分区
ISSN	0304-3940
EISSN	1872-7972
卷号	775
摘要	To improve accuracy of VsEP and avoid the inherent limitation of mechanical vibration, we designed an infrared optical stimulation approach to stimulate mouse vestibular system and measured the evoked potential. IR pulses (1871 nm, 30 pps and 100 μs pulse width) were delivered to mice with different vestibular dysfunction levels and the evoked potential was recorded. The result suggests that the amplitude and latency of the IR-evoked potential (IR-VsEP) were significantly associated with vestibular function integrity. Immunofluorescence staining confirmed that magnitude of IR-VsEP decreased was consistent with the loss of HCs. Micro-CT imaging revealed that the optical fiber was orientating towards the vestibular system. Taken together, we found that: 1) IR stimulation can generate VsEP evoked potential in vestibular system (IR-VsEP), which can be potentially used for vestibular function evaluation; 2) intact HCs and fully functional synaptic transmission are crucial for efficient IR-induced vestibular system stimulation.
关键词	Hair cell Infrared neuron stimulation Vestibular evoked potential Vestibular function evaluation
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	National Natural Science. Foundation of China[81771882] ; 2018 Shenzhen Basic Research Fund[JCYJ20170817104949999] ; Guangdong basic and applied basic research foundation[2020A1515110722] ; Fundamental Research Foundation of Shenzhen Committee of Science, Technology and Innovation[JCYJ20170817111912585] ; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions[2021SHIBS0002] ; Shenzhen Science and Technology Program[JSGG20200225151916021] ; Shenzhen Key Laboratory of Smart Healthcare Engineering[ZDSYS20200811144003009] ; Li Ka Shing Foundation Cross-Disciplinary Research Grant[2020LKSFG13C]
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000763544400002
出版者	ELSEVIER IRELAND LTD
ESI学科分类	NEUROSCIENCE & BEHAVIOR
Scopus记录号	2-s2.0-85126106354
来源库	Scopus
引用统计	被引频次[WOS]：0
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/302167
专题	工学院_生物医学工程系生命科学学院生命科学学院_生物系
作者单位	1.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China 2.R＆D Division,Shengqiang Technology Co. Ltd.,Shenzhen,Longgang District,518055,China 3.Department of Biology,Brain Research Center,Southern University of Science and Technology,Shenzhen,518055,China 4.Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institution,Shenzhen,518055,China 5.Shenzhen Key laboratory of Smart Healthcare Engineering,China
第一作者单位	生物医学工程系
通讯作者单位	生物医学工程系; 生物系; 生命科学学院
第一作者的第一单位	生物医学工程系
推荐引用方式 GB/T 7714	Jiang，Weitao,Wang，Zihan,Xiao，Shijie,et al. Pulsed infrared stimulation evoked electrical potential in mouse vestibular system[J]. NEUROSCIENCE LETTERS,2022,775.
APA	Jiang，Weitao.,Wang，Zihan.,Xiao，Shijie.,Zeng，Dingxuan.,Wu，Zhuli.,...&Chen，Fangyi.(2022).Pulsed infrared stimulation evoked electrical potential in mouse vestibular system.NEUROSCIENCE LETTERS,775.
MLA	Jiang，Weitao,et al."Pulsed infrared stimulation evoked electrical potential in mouse vestibular system".NEUROSCIENCE LETTERS 775(2022).