Shape memory micro-anchors with magnetic guidance for precision micro-vascular deployment

Li，Zhihua1; Chen，Zijian1,2; Gao，Yanan1; Xing，Yi3; Zhou，Yuping1; Luo，Yucheng1; Xu，Weihong1; Chen，Zhengchang1; Gao，Xu1; Gupta，Kapish4; Anbalakan，Karthic2; Chen，Lei1; Liu，Chuang5; Kong，Jian6; Leo，Hwa Liang2; Hu，Chengzhi3; Yu，Hanry4,7,8,9; Guo，Qiongyu1

2022-04-01

10.1016/j.biomaterials.2022.121426

BIOMATERIALS   影响因子和分区

0142-9612

1878-5905

Transcatheter medical micro-devices through circulatory system show great potential for therapy but lack strategies to stably anchor them at the desired site in vascularized tissues to take actions. Here a shape memory functionalized biodegradable magnetic micro-anchor (SMA) is developed to achieve magnetic guided endovascular localization through precisely controlled shape transformation. The SMA comprises anisotropic polylactide-based microparticle embedded with superparamagnetic FeO nanoparticles, exhibiting thermally activated tunable shape recovery modes at a body-friendly temperature range to accomplished an efficient endovascular anchoring effect in both decellularized liver organ and rabbit ear embolization models. The SMA can be anchored at the target micro-vessel, exhibiting a controlled radial expansion of the vessel wall yielding with estimated stresses of 7–26 kPa in contact stress and 38–218 kPa in von Mises stress. The SMA is a promising platform to incorporate diagnostic or therapeutic agents for precision deployment and in-situ action.

Embolotherapy Hyperthermia Magnetic guidance Micro-device Shape memory polymer

EI

英语

第一 ; 通讯

20220911726391

Cardiovascular system ; Magnetism ; Magnetite ; Shape optimization

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Magnetism: Basic Concepts and Phenomena:701.2 ; Optimization Techniques:921.5

MATERIALS SCIENCE

2-s2.0-85125363345

Scopus

1.Shenzhen Key Laboratory of Smart Healthcare Engineering,Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China
2.Department of Biomedical Engineering,National University of Singapore,Singapore,117583,Singapore
3.Department of Mechanical and Energy Engineering,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China
4.Mechanobiology Institute,National University of Singapore,Singapore,117411,Singapore
5.Cryo-EM Center,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China
6.Department of Interventional Radiology,First Affiliated Hospital of Southern University of Science and Technology,Second Clinical Medical College of Jinan University,Shenzhen People's Hospital,Shenzhen,Guangdong,518020,China
7.Institute of Bioengineering and Nanotechnology,Agency for Science,Technology and Research,Singapore,138669,Singapore
8.Department of Physiology,Yong Loo Lin School of Medicine,National University of Singapore,Singapore,117593,Singapore
9.Singapore-MIT Alliance for Research and Technology,Singapore,138602,Singapore

Li，Zhihua,Chen，Zijian,Gao，Yanan,et al. Shape memory micro-anchors with magnetic guidance for precision micro-vascular deployment[J]. BIOMATERIALS,2022,283.

Li，Zhihua.,Chen，Zijian.,Gao，Yanan.,Xing，Yi.,Zhou，Yuping.,...&Guo，Qiongyu.(2022).Shape memory micro-anchors with magnetic guidance for precision micro-vascular deployment.BIOMATERIALS,283.

Li，Zhihua,et al."Shape memory micro-anchors with magnetic guidance for precision micro-vascular deployment".BIOMATERIALS 283(2022).