南方科技大学知识苑(SUSTech KC): Micro-scale Stiffness Change of Cornea Tissues Suffered from Elevated Intraocular Pressure Investigated by Nanoindentation

题名	Micro-scale Stiffness Change of Cornea Tissues Suffered from Elevated Intraocular Pressure Investigated by Nanoindentation
作者	Wu, K. S.1; Li, S. Y.2; Lo, A. C. Y.2; Ngan, A. H. W.1; Wong, D. S. H.2; So, K. F.3,4; Ellis-Behnke, R. G.3,5,6; Tang, B.1,7
通讯作者	Tang, B.
发表日期	2013-07
DOI	10.1080/1539445X.2011.622030
发表期刊	SOFT MATERIALS 影响因子和分区
ISSN	1539-445X
EISSN	1539-4468
卷号	11 期号:3页码:244-253
摘要	Elevated intraocular pressure (IOP) is the main risk factor of glaucoma. In this study, an elevated IOP was introduced into the right eye balls of Sprague-Dawley rats, while their left eye balls were kept at a normal state. Nanoindentation showed that the elastic modulus of normal corneas was 2.75-3.33 MPa, whereas that of elevated IOP group was higher at 4.89-5.58 MPa. Scanning electron microscopy imaging suggested that the collagen fibrils subjected to the elevated IOP became thinner and with random directionality. It is believed the observed increase in elastic modulus should due to the strain-stiffening effects of collagen fibrils.
关键词	Cornea Glaucoma Nanoindentation
相关链接	[来源记录]
收录类别	SCI ; EI
语种	英语
学校署名	通讯
资助项目	University Grants Committee of the Hong Kong Special Administration Region, P.R. China[SEG-HKU06]
WOS研究方向	Materials Science
WOS类目	Materials Science, Multidisciplinary
WOS记录号	WOS:000322306400002
出版者	TAYLOR & FRANCIS INC
EI入藏号	20131016082582
EI主题词	Collagen ; Elastic moduli ; Ophthalmology ; Scanning electron microscopy
EI分类号	Medicine and Pharmacology:461.6 ; Nanotechnology:761 ; Materials Science:951
来源库	Web of Science
引用统计	被引频次[WOS]：15
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/30341
专题	工学院_生物医学工程系
作者单位	1.Univ Hong Kong, Dept Mech Engn, Hong Kong, Hong Kong, Peoples R China 2.Univ Hong Kong, Eye Inst, Hong Kong, Hong Kong, Peoples R China 3.Univ Hong Kong, Dept Anat, Hong Kong, Hong Kong, Peoples R China 4.Ginan Univ, GMH Inst CNS Regenerat, Guangzhou, Guangdong, Peoples R China 5.Heidelberg Univ, Dept Ophthalmol, Med Fac Mannheim, Heidelberg, Germany 6.MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA 7.South Univ Sci & Technol China, Dept Micro Nano Mat & Devices, Shenzhen, Peoples R China
通讯作者单位	生物医学工程系
推荐引用方式 GB/T 7714	Wu, K. S.,Li, S. Y.,Lo, A. C. Y.,et al. Micro-scale Stiffness Change of Cornea Tissues Suffered from Elevated Intraocular Pressure Investigated by Nanoindentation[J]. SOFT MATERIALS,2013,11(3):244-253.
APA	Wu, K. S..,Li, S. Y..,Lo, A. C. Y..,Ngan, A. H. W..,Wong, D. S. H..,...&Tang, B..(2013).Micro-scale Stiffness Change of Cornea Tissues Suffered from Elevated Intraocular Pressure Investigated by Nanoindentation.SOFT MATERIALS,11(3),244-253.
MLA	Wu, K. S.,et al."Micro-scale Stiffness Change of Cornea Tissues Suffered from Elevated Intraocular Pressure Investigated by Nanoindentation".SOFT MATERIALS 11.3(2013):244-253.