Antibacterial activity of ZnO nanoparticles with a modified surface under ambient illumination

Leung, Y. H.1; Chan, C. M. N.2; Ng, A. M. C.1,3; Chan, H. T.4; Chiang, M. W. L.5; Djurisic, A. B.1; Ng, Y. H.1; Jim, W. Y.1; Guo, M. Y.1; Leung, F. C. C.2; Chan, W. K.4; Au, D. T. W.5

2012-11-30

10.1088/0957-4484/23/47/475703

NANOTECHNOLOGY   影响因子和分区

0957-4484

1361-6528

In various practical applications, nanomaterials typically have functionalized surfaces. Yet, the studies of toxicity and antibacterial activity of functionalized nanoparticles are scarce. We investigated the effect of surface modifications on antibacterial activity of ZnO under ambient illumination, and we found that nanoparticles coated with different surface modifying reagents could exhibit higher or lower toxicity compared to bare ZnO, depending on the surface modifying reagent used. Different surface modifying reagent molecules resulted in differences in the release of Zn2+ ions and the production of reactive oxygen species (ROS). However, the antibacterial activity did not correlate with the ROS levels or the Zn2+ ion release. One of the surface-modified ZnO samples exhibited significantly lower Zn2+ ion release while at the same time exhibiting improved antibacterial activity. In all cases, damage of the cell wall membranes and/or changes in the membrane permeability have been observed, together with the changes in ATR-FTIR spectra indicating differences in protein conformation. Mechanisms of antibacterial activity are discussed.

SCI ; EI

英语

其他

RGC CRF[CityU6/CRF/08]

Science & Technology - Other Topics ; Materials Science ; Physics

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied

WOS:000310856100017

IOP PUBLISHING LTD

20124515639731

Chemical reactions ; Fourier transform infrared spectroscopy ; II-VI semiconductors ; Ions ; Nanoparticles ; Toxicity ; Zinc oxide

Health Care:461.7 ; Nanotechnology:761 ; Chemistry:801 ; Chemical Reactions:802.2 ; Inorganic Compounds:804.2 ; Solid State Physics:933

MATERIALS SCIENCE

Web of Science

1.Univ Hong Kong, Dept Phys, Hong Kong, Hong Kong, Peoples R China
2.Univ Hong Kong, Sch Biol Sci, Hong Kong, Hong Kong, Peoples R China
3.S Univ Sci & Technol China, Dept Phys, Shenzhen, Peoples R China
4.Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China
5.City Univ Hong Kong, Dept Biol & Chem, Kowloon Tong, Hong Kong, Peoples R China

Leung, Y. H.,Chan, C. M. N.,Ng, A. M. C.,et al. Antibacterial activity of ZnO nanoparticles with a modified surface under ambient illumination[J]. NANOTECHNOLOGY,2012,23(47).

Leung, Y. H..,Chan, C. M. N..,Ng, A. M. C..,Chan, H. T..,Chiang, M. W. L..,...&Au, D. T. W..(2012).Antibacterial activity of ZnO nanoparticles with a modified surface under ambient illumination.NANOTECHNOLOGY,23(47).

Leung, Y. H.,et al."Antibacterial activity of ZnO nanoparticles with a modified surface under ambient illumination".NANOTECHNOLOGY 23.47(2012).