南方科技大学知识苑(SUSTech KC): A narrative review of research advances in hypoxic pulmonary hypertension

题名	A narrative review of research advances in hypoxic pulmonary hypertension
作者	Chai, Tianci; Qiu, Chen; Xian, Zhihong; Lu, Yongzhen; Zeng, Yuwei; Li, Jie
通讯作者	Li, Jie
发表日期	2022-02-01
DOI	10.21037/atm-22-259
发表期刊	Annals of Translational Medicine 影响因子和分区
ISSN	2305-5839
EISSN	2305-5847
卷号	10 期号:4
摘要	["Background and Objective: Hypoxic pulmonary hypertension (HPH) is a pathological syndrome characterized by pulmonary vasoconstriction and pulmonary vascular remodeling caused by hypoxia, which eventually leads to right heart failure or death. There are 2 stages of onset of HPH: hypoxic pulmonary vasoconstriction (HPV) and hypoxic pulmonary vascular remodeling (HPVR). It is an important pathophysiological link in the pathogenesis of chronic obstructive pulmonary disease (COPD) and chronic mountain sickness (CMS), and its severity is closely related to the course and prognosis of COPD and CMS. However, there is a lack of systematic review on the diagnosis, pathogenesis and treatment of HPH. The objective of this paper is to review the diagnosis, pathogenesis, treatment of HPH.","Methods: In this paper, the method of literature review is adopted to obtain the information about HPH. Based on the literature, comprehensive and systematic review is made. The diagnosis, pathogenesis, treatment of HPH are summarized.","Key Content and Findings: Right heart catheterization is the gold standard for diagnosing HPH. Hypoxia-inducible factor, oxidative stress, metal metabolism, ion channel, inflammatory cytokines, cell apoptosis and vascular factors are the main pathogenesis of HPH. The treatment of HPH includes long-term oxygen therapy, statins, prostaglandins, phosphodiesterase inhibitor and ET receptor antagonists.","Conclusions: Although great progress has been made in the pathophysiology and molecular biology of HPH, it is still unclear which factors play a leading role in the pathogenesis of HPH, and no breakthrough has been made in the treatment of HPH. It is believed that the specific mechanism will be revealed as the research continues, and earlier diagnosis and the development of more effective targeted drugs will be the focus of future research."]
关键词	Hypoxic pulmonary hypertension (HPH) hypoxic pulmonary vasoconstriction (HPV) hypoxic pulmonary vascular remodeling (HPVR) hypoxia-inducible factor (HIF)
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Project of Shenzhen Basic Research Plan[JCYJ20210324114205014] ; Key Laboratory of Shenzhen Respiratory Disease[ZDSYS201504301616234]
WOS研究方向	Oncology ; Research & Experimental Medicine
WOS类目	Oncology ; Medicine, Research & Experimental
WOS记录号	WOS:000766140700071
出版者	AME PUBL CO
来源库	Web of Science
引用统计	被引频次[WOS]：7
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/313201
专题	南方科技大学第一附属医院
作者单位	Southern Univ Sci & Technol, Key Lab Shenzhen Resp Dis, Shenzhen Inst Resp Dis,Jinan Univ, Shenzhen Peoples Hosp,Affiliated Hosp 1,Clin Med, Shenzhen 518020, Peoples R China
第一作者单位	南方科技大学第一附属医院
通讯作者单位	南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Chai, Tianci,Qiu, Chen,Xian, Zhihong,et al. A narrative review of research advances in hypoxic pulmonary hypertension[J]. Annals of Translational Medicine,2022,10(4).
APA	Chai, Tianci,Qiu, Chen,Xian, Zhihong,Lu, Yongzhen,Zeng, Yuwei,&Li, Jie.(2022).A narrative review of research advances in hypoxic pulmonary hypertension.Annals of Translational Medicine,10(4).
MLA	Chai, Tianci,et al."A narrative review of research advances in hypoxic pulmonary hypertension".Annals of Translational Medicine 10.4(2022).