Recent advances in aggregation-induced emission luminogens in photoacoustic imaging

Li, Pei1,2,4; He, Xuewen2,3; Li, Yang1,5; Lam, Jacky Wing Yip2,3; Kwok, Ryan Tsz Kin2,3; Wang, Cun Chuan4; Xia, Li Gang1,5; Tang, Ben Zhong2,3,6

2022-03-01

10.1007/s00259-022-05726-8

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING   影响因子和分区

1619-7070

1619-7089

Photoacoustic imaging (PAI) is a rapidly emerging modality in biomedical research with the advantages of noncontact operation, high optical resolution, and deep penetration. Great efforts and progress in the development of PAI agents with improved imaging resolution and sensitivity have been made over the past 2 decades. Among them, organic agents are the most promising candidates for preclinical/clinical applications due to their outstanding in vivo properties and facile biofunctionalities. Motivated by the unique properties of aggregation-induced emission (AIE) luminogens (AIEgens), various optical probes have been developed for bioanalyte detection, multimodal bioimaging, photodynamic/photothermal therapy, and imaging-guided therapeutics. In particular, AIE-active contrast agents have been demonstrated in PAI applications with excellent performance in imaging resolution and tissue permeability in vivo. This paper presents a brief overview of recent progress in AIE-based agents in the field of photoacoustic imaging. In particular, we focus on the basic concepts, data sorting and comparison, developing trends, and perspectives of photoacoustic imaging. Through numerous typical examples, the way each system realizes the desired photoacoustic performance in various biomedical applications is clearly illustrated. We believe that AIE-based PAI agents would be promising multifunctional theranostic platforms in clinical fields and will facilitate significant advancements in this research topic.

Photoacoustic Aggregation-induced emission Fluorescence Contrast agents Biomedical applications

SCI

英语

第一 ; 通讯

Research Grants Council of Hong Kong[16306620,"N-HKUST609/19","C6014-20W"] ; National Natural Science Foundation of China[21788102] ; Innovation and Technology Commission["ITC-CNERC14SC01","ITCPD/17-9"] ; General Program of Shenzhen Science and Technology Innovation Commission[JCYJ20190807144209381] ; Shenzhen Key Medical Discipline Construction Fund[SZXK015] ; National Natural Youth Foundation of China[81901771]

Radiology, Nuclear Medicine & Medical Imaging

Radiology, Nuclear Medicine & Medical Imaging

WOS:000767740100002

SPRINGER

CLINICAL MEDICINE

Web of Science

1.Southern Univ Sci & Technol, Affiliated Hosp 1, Jinan Univ,Dept Gastrointestinal Surg, Shenzhen Peoples Hosp,Clin Med Coll 2, Shenzhen 518020, Peoples R China
2.Hong Kong Univ Sci & Technol, Dept Chem, Hong Kong Branch Chinese Natl Engn Res Ctr Tissue, Div Life Sci,Kowloon, Clear Water Bay, Hong Kong, Peoples R China
3.Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Kowloon, Clear Water Bay, Hong Kong, Peoples R China
4.Jinan Univ, Affiliated Hosp 1, Guangzhou 510632, Peoples R China
5.Shenzhen Peoples Hosp, Dept Gen Surg, Shenzhen 518020, Guangdong, Peoples R China
6.Chinese Univ Hong Kong, Shenzhen Inst Mol Aggregate Sci & Engn, Sch Sci & Engn, 2001 Longxiang Blvd, Shenzhen 518172, Guangdong, Peoples R China

Li, Pei,He, Xuewen,Li, Yang,et al. Recent advances in aggregation-induced emission luminogens in photoacoustic imaging[J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,2022.

Li, Pei.,He, Xuewen.,Li, Yang.,Lam, Jacky Wing Yip.,Kwok, Ryan Tsz Kin.,...&Tang, Ben Zhong.(2022).Recent advances in aggregation-induced emission luminogens in photoacoustic imaging.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING.

Li, Pei,et al."Recent advances in aggregation-induced emission luminogens in photoacoustic imaging".EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022).