Strontium based Astragalus polysaccharides promote osteoblasts differentiation and mineralization

Peng，Ying1; Ma，Fenbo1; Hu，Liqiu1; Deng，Yuqing1; He，Wenqi1; Tang，Bin1,2,3

2022-04-30

10.1016/j.ijbiomac.2022.03.088

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES   影响因子和分区

0141-8130

1879-0003

Bone formation and repair represent a clinical challenge. In this work, we designed and synthesized strontium Astragalus polysaccharide (APS-Sr), a novel polysaccharide compound that should have therapeutic effects on both anti-inflammation and promoting bone formation. Using material characterization techniques, including SEM, FITR, XRD, etc., we verified the successful synthesis of this compound. Moreover, we examined the potential of this compound for promoting bone repair and inhibiting inflammatory response by cell proliferation assay, ALP and Alizarin Red staining experiments and RT-qPCR. The biological experiment results showed that APS-Sr can effectively inhibit inflammatory factors, promote osteogenic differentiation and up-regulate the bone growth factors. It is therefore believed that APS-Sr should be a promising polysaccharide compound in bone-related biomedical applications.

Astragalus polysaccharide Bone Inflammatory MC3T3-E1

SCI

英语

第一 ; 通讯

National Natural Science Foundation of China[11872200];Science, Technology and Innovation Commission of Shenzhen Municipality[JCYJ20170817111312887];Science, Technology and Innovation Commission of Shenzhen Municipality[KQJSCX20180319114439683];

Biochemistry & Molecular Biology ; Chemistry ; Polymer Science

Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science

WOS:000796858000005

ELSEVIER

BIOLOGY & BIOCHEMISTRY

2-s2.0-85126868938

Scopus

1.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,Guangdong,China
2.Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,China
3.Shenzhen Key Laboratory of Cell Microenvironment,China

Peng，Ying,Ma，Fenbo,Hu，Liqiu,et al. Strontium based Astragalus polysaccharides promote osteoblasts differentiation and mineralization[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2022,205:761-771.

Peng，Ying,Ma，Fenbo,Hu，Liqiu,Deng，Yuqing,He，Wenqi,&Tang，Bin.(2022).Strontium based Astragalus polysaccharides promote osteoblasts differentiation and mineralization.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,205,761-771.

Peng，Ying,et al."Strontium based Astragalus polysaccharides promote osteoblasts differentiation and mineralization".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 205(2022):761-771.