[4 + 1] Cyclization of benzohydrazide and ClCF2COONa towards 1,3,4-oxadiazoles and 1,3,4-oxadiazoles-d5

Wang，Ya1; Mu，Shiqiang1; Li，Xin1; Song，Qiuling1,2,3

2022-03-01

10.1016/j.cclet.2021.08.089

CHINESE CHEMICAL LETTERS   影响因子和分区

1001-8417

1878-5964

A facile synthesis of 1,3,4-oxadiazoles and 1,3,4-oxadiazoles-d via [4 + 1] cyclization of ClCFCOONa with non-amine compounds containing amino groups is developed. Of note, this is the first time that halofluorinated compounds are used as C1 synthon to construct deuterated nitrogen-heterocyclic compounds. The current protocol features simple operation, readily accessible raw materials, wide substrate scope and valuable products

1,3,4-Oxadiazoles Halofluorinated compounds Transition-metal-free catalyzed [4 + 1] Cyclization

SCI

英语

通讯

Guangdong Provincial Key Laboratory of Environmental Catalysis and Health Risk Control, Guangdong University of Technology[2020B121201002];National Natural Science Foundation of China[21772046];National Natural Science Foundation of China[2193103];

Chemistry

Chemistry, Multidisciplinary

WOS:000772416400066

ELSEVIER SCIENCE INC

CHEMISTRY

2-s2.0-85115028973

Scopus

1.Institute of Next Generation Matter Transformation,College of Materials Science & Engineering and College of Chemical Engineering at Huaqiao University,Xiamen,361021,China
2.Guangdong Provincial Key Laboratory of Catalysis,Southern University of Science and Technology,Shenzhen,518055,China
3.State Key Laboratory of Organometallic Chemistry and Key Laboratory of Organofluorine Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai,200032,China

Wang，Ya,Mu，Shiqiang,Li，Xin,等. [4 + 1] Cyclization of benzohydrazide and ClCF2COONa towards 1,3,4-oxadiazoles and 1,3,4-oxadiazoles-d5[J]. CHINESE CHEMICAL LETTERS,2022,33(3):1511-1514.

Wang，Ya,Mu，Shiqiang,Li，Xin,&Song，Qiuling.(2022).[4 + 1] Cyclization of benzohydrazide and ClCF2COONa towards 1,3,4-oxadiazoles and 1,3,4-oxadiazoles-d5.CHINESE CHEMICAL LETTERS,33(3),1511-1514.

Wang，Ya,et al."[4 + 1] Cyclization of benzohydrazide and ClCF2COONa towards 1,3,4-oxadiazoles and 1,3,4-oxadiazoles-d5".CHINESE CHEMICAL LETTERS 33.3(2022):1511-1514.