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题名

Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2

作者
通讯作者Qi,Jianxun; Gao,George F.; Wang,Peiyi; Qi,Jianxun; Gao,George F.; Wang,Peiyi
发表日期
2022-02-17
DOI
发表期刊
ISSN
0092-8674
EISSN
1097-4172
卷号185期号:4页码:630-640.e10
摘要

The coronavirus disease 2019 (COVID-19) pandemic continues worldwide with many variants arising, some of which are variants of concern (VOCs). A recent VOC, omicron (B.1.1.529), which obtains a large number of mutations in the receptor-binding domain (RBD) of the spike protein, has risen to intense scientific and public attention. Here, we studied the binding properties between the human receptor ACE2 (hACE2) and the VOC RBDs and resolved the crystal and cryoelectron microscopy structures of the omicron RBD-hACE2 complex as well as the crystal structure of the delta RBD-hACE2 complex. We found that, unlike alpha, beta, and gamma, omicron RBD binds to hACE2 at a similar affinity to that of the prototype RBD, which might be due to compensation of multiple mutations for both immune escape and transmissibility. The complex structures of omicron RBD-hACE2 and delta RBD-hACE2 reveal the structural basis of how RBD-specific mutations bind to hACE2.

关键词
相关链接[Scopus记录]
收录类别
语种
英语
重要成果
ESI高被引 ; NI论文
学校署名
通讯
资助项目
Chinese Academy of Sciences[XDB29010202] ; Chinese Academy of Sciences[XDB37030204]
WOS研究方向
Biochemistry & Molecular Biology ; Cell Biology
WOS类目
Biochemistry & Molecular Biology ; Cell Biology
WOS记录号
WOS:000768265900006
出版者
ESI学科分类
MOLECULAR BIOLOGY & GENETICS
Scopus记录号
2-s2.0-85123715877
来源库
Scopus
引用统计
被引频次[WOS]:324
成果类型期刊论文
条目标识符http://sustech.caswiz.com/handle/2SGJ60CL/327729
专题生命科学学院_生物系
生命科学学院
冷冻电镜中心
作者单位
1.CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing,100101,China
2.School of Medicine,Zhongda Hospital,Southeast University,NanJing,210009,China
3.University of Chinese Academy of Sciences,Beijing,100049,China
4.Cryo-EM Center,Department of Biology,Southern University of Science and Technology,Shenzhen,518055,China
5.Shanghai Synchrotron Radiation Facility,Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai,201204,China
6.Faculty of Health Sciences,University of Macau,Macau,999078,China
7.Cryo-EM Center,Shanxi Academy of Advanced Research and Innovation,Taiyuan,030032,China
8.Department of Biomedical Sciences,City University of Hong Kong,Hong Kong,999077,Hong Kong
9.College of life Science,Shanxi University,Taiyuan,03006,China
10.CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing,100101,China
11.School of Medicine,Zhongda Hospital,Southeast University,NanJing,210009,China
12.University of Chinese Academy of Sciences,Beijing,100049,China
13.Cryo-EM Center,Department of Biology,Southern University of Science and Technology,Shenzhen,518055,China
14.Shanghai Synchrotron Radiation Facility,Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai,201204,China
15.Faculty of Health Sciences,University of Macau,Macau,999078,China
16.Cryo-EM Center,Shanxi Academy of Advanced Research and Innovation,Taiyuan,030032,China
17.Department of Biomedical Sciences,City University of Hong Kong,Hong Kong,999077,Hong Kong
18.College of life Science,Shanxi University,Taiyuan,03006,China
通讯作者单位生物系;  生命科学学院
推荐引用方式
GB/T 7714
Han,Pengcheng,Li,Linjie,Liu,Sheng,et al. Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2[J]. CELL,2022,185(4):630-640.e10.
APA
Han,Pengcheng.,Li,Linjie.,Liu,Sheng.,Wang,Qisheng.,Zhang,Di.,...&Wang,Peiyi.(2022).Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2.CELL,185(4),630-640.e10.
MLA
Han,Pengcheng,et al."Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2".CELL 185.4(2022):630-640.e10.
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