题名 | Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2 |
作者 | Han,Pengcheng1,2; Li,Linjie1,3; Liu,Sheng4 ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
通讯作者 | Qi,Jianxun; Gao,George F.; Wang,Peiyi; Qi,Jianxun; Gao,George F.; Wang,Peiyi |
发表日期 | 2022-02-17
|
DOI | |
发表期刊 | |
ISSN | 0092-8674
|
EISSN | 1097-4172
|
卷号 | 185期号:4页码:630-640.e10 |
摘要 | The coronavirus disease 2019 (COVID-19) pandemic continues worldwide with many variants arising, some of which are variants of concern (VOCs). A recent VOC, omicron (B.1.1.529), which obtains a large number of mutations in the receptor-binding domain (RBD) of the spike protein, has risen to intense scientific and public attention. Here, we studied the binding properties between the human receptor ACE2 (hACE2) and the VOC RBDs and resolved the crystal and cryoelectron microscopy structures of the omicron RBD-hACE2 complex as well as the crystal structure of the delta RBD-hACE2 complex. We found that, unlike alpha, beta, and gamma, omicron RBD binds to hACE2 at a similar affinity to that of the prototype RBD, which might be due to compensation of multiple mutations for both immune escape and transmissibility. The complex structures of omicron RBD-hACE2 and delta RBD-hACE2 reveal the structural basis of how RBD-specific mutations bind to hACE2. |
关键词 | |
相关链接 | [Scopus记录] |
收录类别 | |
语种 | 英语
|
重要成果 | ESI高被引
; NI论文
|
学校署名 | 通讯
|
资助项目 | Chinese Academy of Sciences[XDB29010202]
; Chinese Academy of Sciences[XDB37030204]
|
WOS研究方向 | Biochemistry & Molecular Biology
; Cell Biology
|
WOS类目 | Biochemistry & Molecular Biology
; Cell Biology
|
WOS记录号 | WOS:000768265900006
|
出版者 | |
ESI学科分类 | MOLECULAR BIOLOGY & GENETICS
|
Scopus记录号 | 2-s2.0-85123715877
|
来源库 | Scopus
|
引用统计 |
被引频次[WOS]:324
|
成果类型 | 期刊论文 |
条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/327729 |
专题 | 生命科学学院_生物系 生命科学学院 冷冻电镜中心 |
作者单位 | 1.CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing,100101,China 2.School of Medicine,Zhongda Hospital,Southeast University,NanJing,210009,China 3.University of Chinese Academy of Sciences,Beijing,100049,China 4.Cryo-EM Center,Department of Biology,Southern University of Science and Technology,Shenzhen,518055,China 5.Shanghai Synchrotron Radiation Facility,Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai,201204,China 6.Faculty of Health Sciences,University of Macau,Macau,999078,China 7.Cryo-EM Center,Shanxi Academy of Advanced Research and Innovation,Taiyuan,030032,China 8.Department of Biomedical Sciences,City University of Hong Kong,Hong Kong,999077,Hong Kong 9.College of life Science,Shanxi University,Taiyuan,03006,China 10.CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing,100101,China 11.School of Medicine,Zhongda Hospital,Southeast University,NanJing,210009,China 12.University of Chinese Academy of Sciences,Beijing,100049,China 13.Cryo-EM Center,Department of Biology,Southern University of Science and Technology,Shenzhen,518055,China 14.Shanghai Synchrotron Radiation Facility,Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai,201204,China 15.Faculty of Health Sciences,University of Macau,Macau,999078,China 16.Cryo-EM Center,Shanxi Academy of Advanced Research and Innovation,Taiyuan,030032,China 17.Department of Biomedical Sciences,City University of Hong Kong,Hong Kong,999077,Hong Kong 18.College of life Science,Shanxi University,Taiyuan,03006,China |
通讯作者单位 | 生物系; 生命科学学院 |
推荐引用方式 GB/T 7714 |
Han,Pengcheng,Li,Linjie,Liu,Sheng,et al. Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2[J]. CELL,2022,185(4):630-640.e10.
|
APA |
Han,Pengcheng.,Li,Linjie.,Liu,Sheng.,Wang,Qisheng.,Zhang,Di.,...&Wang,Peiyi.(2022).Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2.CELL,185(4),630-640.e10.
|
MLA |
Han,Pengcheng,et al."Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2".CELL 185.4(2022):630-640.e10.
|
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | 操作 | |
2022.02-Receptor bin(6529KB) | -- | -- | 限制开放 | -- |
|
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论