Bioeffects of Inhaled Nanoplastics on Neurons and Alteration of Animal Behaviors through Deposition in the Brain

Liu，Xiaoyan1,2,3; Zhao，Yingcan1; Dou，Jiabin1,2; Hou，Qinghong1; Cheng，Jinxiong1; Jiang，Xingyu1,2

2022-02-09

10.1021/acs.nanolett.1c04184

NANO LETTERS   影响因子和分区

1530-6984

1530-6992

The potential toxicity of nanoplastics on plants has previously been illustrated, but whether nanoplastics could cause neurotoxicity, especially to higher animals, remains unclear. We now demonstrate that nanoplastics can be deposited in the brain via nasal inhalation, triggering neuron toxicity and altering the animal behavior. Polystyrene nanoparticles (PS-NPs) of PS-COOH and PS-NH2 are used as models for nanoplastics. We designed a microfluidic chip to evaluate the PS-NPs with different concentrations, surface ligands, and sizes to interact with neurons. Smaller PS-NPs can induce more cellular uptake than larger PS-NPs. PS-NPs with a size of 80 nm can reach and deposit in the brain of mice via aerosol inhalation. Mice inhaling PS-NPs exhibit fewer activities in comparison to those inhaling water droplets. An obvious neurotoxicity of the nanoplastics could be observed from the results of the inhibition of AChE activities. Our results show the potential significance of the physiochemical properties of organic nanoplastics on depositing in mammalian brains by nasal inhalation.

animal behaviors brain inhalation of nanoplastic neuronal uptake size surface ligand

SCI ; EI

英语

NI论文

第一 ; 通讯

National Natural Science Foundation of China[81730051];Shenzhen Peacock Plan[KQTD20190929172743294];Chinese Academy of Sciences[QYZDJ-SSW-SLH039];

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000777171600029

AMER CHEMICAL SOC

20220611602399

Brain ; Ligands ; Mammals ; Toxicity

Biomedical Engineering:461.1 ; Health Care:461.7 ; Biology:461.9 ; Physical Chemistry:801.4

MATERIALS SCIENCE

2-s2.0-85124076104

Scopus

1.Shenzhen Key Laboratory of Smart Healthcare Engineering,Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,No. 1088 Xueyuan Road, Nanshan District, Guangdong,518055,China
2.Cas Center for Excellence in Nanoscience,National Center for NanoScience and Technology,University of Chinese Academy of Sciences,Beijing,No. 11 Zhongguancun Beiyitiao,100190,China
3.Academy for Advanced Interdisciplinary Studies,Peking University,Beijing,100871,China

Liu，Xiaoyan,Zhao，Yingcan,Dou，Jiabin,et al. Bioeffects of Inhaled Nanoplastics on Neurons and Alteration of Animal Behaviors through Deposition in the Brain[J]. NANO LETTERS,2022,22(3):1091-1099.

Liu，Xiaoyan,Zhao，Yingcan,Dou，Jiabin,Hou，Qinghong,Cheng，Jinxiong,&Jiang，Xingyu.(2022).Bioeffects of Inhaled Nanoplastics on Neurons and Alteration of Animal Behaviors through Deposition in the Brain.NANO LETTERS,22(3),1091-1099.

Liu，Xiaoyan,et al."Bioeffects of Inhaled Nanoplastics on Neurons and Alteration of Animal Behaviors through Deposition in the Brain".NANO LETTERS 22.3(2022):1091-1099.