Hsp90 Inhibitors Prevent HSV-1 Replication by Directly Targeting UL42-Hsp90 Complex

Qin，Shurong1,2,3,4; Hu，Xiao1,2,3,4; Lin，Shimin1,2,3; Xiao，Ji1,2,3; Wang，Zhaoyang1,2,3; Jia，Jiaoyan1,2,3; Song，Xiaowei1,2,3; Liu，Kaisheng5; Ren，Zhe1,2,3; Wang，Yifei1,2,3

2022-02-03

10.3389/fmicb.2021.797279

Frontiers in Microbiology   影响因子和分区

1664-302X

Herpes simplex virus type I (HSV-1) is a member of the Alphaherpesvirinae family, which could initiate labial herpes caused by the reactivation of HSV-1 primary infection, and secondary infection even causes herpes encephalitis. The study presented here demonstrates that Hsp90 inhibitors (AT-533 and 17-AAG) directly targeted the HSV-1 UL42-Hsp90 complex, and Hsp90 interacted with HSV-1 UL42 in silicon and experiment. Interestingly, Hsp90 inhibitors also reduced virus titers of ACV-resistant clinical HSV-1 strains (153 and blue strain), revealing that HSV-1 UL42 would be a new target against ACV-resistant HSV-1 strains. Altogether, this present study indicates that Hsp90 inhibitors prevent HSV-1 proliferation by regulating the interaction between Hsp90 and HSV-1 UL42, suggesting a promising target for anti-HSV-1 therapies in the replication.

17-AAG AT-533 DNA replication HSV-1 protein docking UL42

SCI

英语

其他

WOS:000759922300001

2-s2.0-85124870716

Scopus

1.Guangzhou Jinan Biomedical Research and Development Center,College of Life Science and Technology,Institute of Biomedicine,Jinan University,Guangzhou,China
2.Key Laboratory of Virology of Guangzhou,Jinan University,Guangzhou,China
3.Key Laboratory of Bioengineering Medicine of Guangdong Province,Jinan University,Guangzhou,China
4.College of Pharmacy,Jinan University,Guangzhou,China
5.Shenzhen People’s Hospital,The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,China

Qin，Shurong,Hu，Xiao,Lin，Shimin,et al. Hsp90 Inhibitors Prevent HSV-1 Replication by Directly Targeting UL42-Hsp90 Complex[J]. Frontiers in Microbiology,2022,12.

Qin，Shurong.,Hu，Xiao.,Lin，Shimin.,Xiao，Ji.,Wang，Zhaoyang.,...&Wang，Yifei.(2022).Hsp90 Inhibitors Prevent HSV-1 Replication by Directly Targeting UL42-Hsp90 Complex.Frontiers in Microbiology,12.

Qin，Shurong,et al."Hsp90 Inhibitors Prevent HSV-1 Replication by Directly Targeting UL42-Hsp90 Complex".Frontiers in Microbiology 12(2022).