南方科技大学知识苑(SUSTech KC): COVID-19-associated pulmonary aspergillosis in a tertiary care center in Shenzhen City

题名	COVID-19-associated pulmonary aspergillosis in a tertiary care center in Shenzhen City
作者	Jiang，Zhaofang; Chen，Shuyan; Zhu，Qing; Xiao，Yanyu; Qu，Jiuxin
通讯作者	Qu，Jiuxin
发表日期	2022-02-01
DOI	10.1016/j.jiph.2021.12.015
发表期刊	Journal of Infection and Public Health 影响因子和分区
ISSN	1876-0341
EISSN	1876-035X
卷号	15 期号:2页码:222-227
摘要	Objectives: The severe coronavirus disease 2019 (COVID-19) is characterized by acute respiratory distress syndrome (ARDS) and risk of fungal co-infection, pulmonary aspergillosis in particular. However, COVID-19 associated pulmonary aspergillosis (CAPA) cases remain limited due to the difficulty in diagnosis. Methods: We describe presumptive invasive aspergillosis in eight patients diagnosed with COVID-19 in a single center in Shenzhen, China. Data collected include underlying conditions, mycological findings, immunodetection results, therapies and outcomes. Results: Four of the eight patients had tested positive for Aspergillus by either culture or Next-generation sequencing analysis of sputum or bronchoalveolar lavage fluid (BALF), while the rest of patients had only positive results in antigen or antibody detection. Although all patients received antifungal therapies, six of these eight patients (66.7%) died. Conclusion: Due to the high mortality rate of CAPA, clinical care in patients with CAPA deserves more attention.
关键词	Anti-Aspergillus IgG COVID-19 Galactomannan Pulmonary aspergillosis
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Guangdong Basic and Applied Basic Research Foundation[2020A1515010586] ; Science and Technology program of Shenzhen[JCYJ20190809144005609] ; Special Sup-port Fund of Shenzhen for Introduced High-Level Medical Team[SZSM201412005]
WOS研究方向	Public, Environmental & Occupational Health ; Infectious Diseases
WOS类目	Public, Environmental & Occupational Health ; Infectious Diseases
WOS记录号	WOS:000784299300011
出版者	ELSEVIER SCIENCE LONDON
Scopus记录号	2-s2.0-85122610078
来源库	Scopus
引用统计	被引频次[WOS]：5
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/327774
专题	南方科技大学第二附属医院
作者单位	The Third People's Hospital of Shenzhen,Southern University of Science and Technology,National Clinical Research Center for Infectious Diseases,Shenzhen,China
第一作者单位	南方科技大学第二附属医院
通讯作者单位	南方科技大学第二附属医院
第一作者的第一单位	南方科技大学第二附属医院
推荐引用方式 GB/T 7714	Jiang，Zhaofang,Chen，Shuyan,Zhu，Qing,et al. COVID-19-associated pulmonary aspergillosis in a tertiary care center in Shenzhen City[J]. Journal of Infection and Public Health,2022,15(2):222-227.
APA	Jiang，Zhaofang,Chen，Shuyan,Zhu，Qing,Xiao，Yanyu,&Qu，Jiuxin.(2022).COVID-19-associated pulmonary aspergillosis in a tertiary care center in Shenzhen City.Journal of Infection and Public Health,15(2),222-227.
MLA	Jiang，Zhaofang,et al."COVID-19-associated pulmonary aspergillosis in a tertiary care center in Shenzhen City".Journal of Infection and Public Health 15.2(2022):222-227.