Comprehensive Analysis of Immune Infiltrates of Ferroptosis-Related Long Noncoding RNA and Prediction of Colon Cancer Patient Prognoses

Chen，Wenzheng1,2; Chen，Yafei3; Liu，Li4; Wu，Yukang4; Fu，Pengcheng4; Cao，Yi1; Xiong，Jianbo1; Tu，Yi5; Li，Zhengrong1; Liu，Yi1; Jie，Zhigang1

2022

10.1155/2022/9480628

Journal of Immunology Research   影响因子和分区

2314-8861

2314-7156

Ferroptosis is a newly defined mode of programmed oxidative cell death. Knowledge of ferroptosis-related long noncoding (lnc) RNA in the tumor immune microenvironment of colon cancer is lacking. We systematically analyzed the correlations between ferroptosis-related lncRNAs and the tumor microenvironment, immune cell infiltration, and patient prognosis for 379 colon cancer samples in the Cancer Genome Atlas (TCGA). Using consensus clustering, we divided the 379 colon cancer patients into two subgroups (clusters 1 and 2) based on the differentially expressed ferroptosis-related lncRNAs. Cluster 1 was preferentially associated with longer overall survival, upregulated immune checkpoint inhibitor expressions, higher immunoscores, higher stromal scores, higher estimated scores, and distinct immune cell infiltration. Cancer- and metabolism-related pathways were enriched by gene set enrichment analyses. We constructed a prognostic signature of 15 ferroptosis-related lncRNAs (ZEB1-AS1, LINC01011, AC005261.3, LINC01063, LINC02381, ELFN1-AS1, AC009283.1, LINC02361, AC105219.1, AC002310.1, AL590483.1, MIR4435-2HG, NKILA, AC021054.1, and AL450326.1) and divided the patients into the high- and low-risk-score groups. The signature was validated using TCGA training and testing cohorts. The risk signature was an independent prognostic factor for predicting survival and excellently predicted the prognoses of patients with colon cancer. Moreover, the risk signature was related to immune characteristics. Chemosensitivity analyses showed that low-risk-score patients were more sensitive to sorafenib. In summary, our work revealed the important role of ferroptosis-related lncRNAs in the tumor microenvironment and immune cell infiltration and may help determine personalized prognoses and treatment for patients with colon cancer.

SCI

英语

其他

National Natural Science Foundation[81960503] ; Key R&D General Project of Jiangxi Science and Technology Department[20203BBGL73187]

Immunology

Immunology

WOS:000784166200001

HINDAWI LTD

2-s2.0-85126166190

Scopus

1.Department of Gastrointestinal Surgery,The First Affiliated Hospital of Nanchang University,China
2.Jiangxi Province Cancer Hospital,China
3.School of Medicine,Southern University of Science and Technology,China
4.Medical College of Nanchang University,China
5.Department of Pathology,The First Affiliated Hospital of Nanchang University,China

Chen，Wenzheng,Chen，Yafei,Liu，Li,et al. Comprehensive Analysis of Immune Infiltrates of Ferroptosis-Related Long Noncoding RNA and Prediction of Colon Cancer Patient Prognoses[J]. Journal of Immunology Research,2022,2022.

Chen，Wenzheng.,Chen，Yafei.,Liu，Li.,Wu，Yukang.,Fu，Pengcheng.,...&Jie，Zhigang.(2022).Comprehensive Analysis of Immune Infiltrates of Ferroptosis-Related Long Noncoding RNA and Prediction of Colon Cancer Patient Prognoses.Journal of Immunology Research,2022.

Chen，Wenzheng,et al."Comprehensive Analysis of Immune Infiltrates of Ferroptosis-Related Long Noncoding RNA and Prediction of Colon Cancer Patient Prognoses".Journal of Immunology Research 2022(2022).