Experimental study on the role and mechanism of Allicin in ventricular remodeling through PPARα and PPARγ signaling pathways

Liu，Qiyun1,2,3,4; Fu，Qian5; Du，Jia6; Liu，Xiaohui6

2022

10.1590/fst.31121

Food Science and Technology (Brazil)   影响因子和分区

1678-457X

1678-457X

The paper investigated the effects of Allicin on the changes of activities of PPARα and PPARγ signaling pathways, and the relations with the subsequent myocardial cell hypertrophy, apoptosis, myocardial interstitial remodeling, RAAS activation and heart failure. The heart obtained from the 1-day-old Wistar suckling rats was isolated and cultured in an ordinary medium. After adding AngII and AngII+ of different concentrations respectively, the conditions of cardiomyocyte hypertrophy, apoptosis and interstitial remodeling were observed. AngII activated the re-expression of β-MHC in cardiomyocytes, which increased the area of cardiomyocytes, indicating that myocardial hypertrophy had occurred, and the model of cardiomyocyte hypertrophy was successfully established. Compared with the control group, after being treated with different concentrations of Allicin for 24 h, the AngII-induced cardiomyocyte hypertrophy was significantly reversed, α-MHC expression increased, β-MHC expression decreased, and α/β-MHC ratio obviously increased. Allicin inhibited AngII-induced cardiomyocyte apoptosis, decreased Fas/FasL protein expression, increased Bcl-2 protein expression, and decreased Bax protein expression. The Bcl-2/Bax ratio increased significantly. PPARα and PPARγ signaling pathways are involved in the inhibition of cardiomyocyte hypertrophy. Allicin-activated PPARα and PPARγ pathways can reverse cardiomyocyte hypertrophy, inhibit cardiomyocyte apoptosis, and alter expressions of Bcl-2/Bax and Fas/Fas-L in apoptosis-related gene.

Allicin PPARα PPARγ signaling pathway Ventricular remodeling

SCI

英语

其他

Shenzhen Key Medical Discipline Construction Fund[2019CFB393]

Food Science & Technology

Food Science & Technology

WOS:000783628100009

SOC BRASILEIRA CIENCIA TECNOLOGIA ALIMENTOS

2-s2.0-85126110544

Scopus

1.Department of Cardiology,Shenzhen People’s Hospital,Shenzhen,Guandong,China
2.Shenzhen Cardiovascular Minimally Invasive Medical Engineering Technology Research and Development Center,Shenzhen,Guandong,China
3.The Second Clinical Medical College,Jinan University,Shenzhen,Guandong,China
4.Southern University of Science and Technology,Shenzhen,Guandong,China
5.Department of Ultrasound Imaging,Shenzhen Maternity and Child Health Hospital Affiliated to Southern Medical,University,Shenzhen,Guandong,China
6.Department of Pathology and Laboratory Medicine,Wuhan Asia Heart Hospital,Wuhan,Hubei,China

Liu，Qiyun,Fu，Qian,Du，Jia,et al. Experimental study on the role and mechanism of Allicin in ventricular remodeling through PPARα and PPARγ signaling pathways[J]. Food Science and Technology (Brazil),2022,42.

Liu，Qiyun,Fu，Qian,Du，Jia,&Liu，Xiaohui.(2022).Experimental study on the role and mechanism of Allicin in ventricular remodeling through PPARα and PPARγ signaling pathways.Food Science and Technology (Brazil),42.

Liu，Qiyun,et al."Experimental study on the role and mechanism of Allicin in ventricular remodeling through PPARα and PPARγ signaling pathways".Food Science and Technology (Brazil) 42(2022).