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题名

Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway in Vitro

作者
通讯作者Yang,Liu; Pei,Guo Xian
发表日期
2022
DOI
发表期刊
ISSN
1687-966X
EISSN
1687-9678
卷号2022
摘要

Schwann cells have been found to promote osteogenesis by an unclear molecular mechanism. To better understand how Schwann cells accelerate osteogenesis, RNA-Seq and LC-MS/MS were utilized to explore the transcriptomic and metabolic response of MC3T3-E1 to Schwann cells. Osteogenic differentiation was determined by ALP staining. Lentiviruses were constructed to alter the expression of Mif (macrophage migration inhibitory factor) in Schwann cells. Western blot (WB) analysis was employed to detect the protein expression. The results of this study show that Mif is essential for Schwann cells to promote osteogenesis, and its downstream CD74/FOXO1 is also involved in the promotion of Schwann cells on osteogenesis. Further, Schwann cells regulate amino acid metabolism and lipid metabolism in preosteoblasts. These findings unveil the mechanism for Schwann cells to promote osteogenesis where Mif is a key factor.

相关链接[Scopus记录]
收录类别
语种
英语
学校署名
通讯
资助项目
Supporting funds for scientific research of Southern University of Science and Technology[Y01416214] ; NSFCs Youth Program of National Natural Science Foundation of China[81902202]
WOS研究方向
Cell Biology
WOS类目
Cell & Tissue Engineering
WOS记录号
WOS:000772085500001
出版者
Scopus记录号
2-s2.0-85123526580
来源库
Scopus
引用统计
被引频次[WOS]:3
成果类型期刊论文
条目标识符http://sustech.caswiz.com/handle/2SGJ60CL/327937
专题南方科技大学医院
南方科技大学医学院
作者单位
1.Department of Orthopaedics,Xijing Hospital,Air Force Medical University,Xi'an,710032,China
2.Southern University of Science and Technology Hospital,Shenzhen,No. 6019 Liuxian Street, Xili Avenue, Nanshan District,518055,China
3.School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China
第一作者单位南方科技大学医院;  南方科技大学医学院
通讯作者单位南方科技大学医院;  南方科技大学医学院
推荐引用方式
GB/T 7714
Li,Jun Qin,Jiang,Hui Jie,Su,Xiu Yun,et al. Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway in Vitro[J]. Stem Cells International,2022,2022.
APA
Li,Jun Qin.,Jiang,Hui Jie.,Su,Xiu Yun.,Feng,Li.,Zhan,Na Zhi.,...&Pei,Guo Xian.(2022).Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway in Vitro.Stem Cells International,2022.
MLA
Li,Jun Qin,et al."Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway in Vitro".Stem Cells International 2022(2022).
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