题名 | Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway in Vitro |
作者 | |
通讯作者 | Yang,Liu; Pei,Guo Xian |
发表日期 | 2022
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DOI | |
发表期刊 | |
ISSN | 1687-966X
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EISSN | 1687-9678
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卷号 | 2022 |
摘要 | Schwann cells have been found to promote osteogenesis by an unclear molecular mechanism. To better understand how Schwann cells accelerate osteogenesis, RNA-Seq and LC-MS/MS were utilized to explore the transcriptomic and metabolic response of MC3T3-E1 to Schwann cells. Osteogenic differentiation was determined by ALP staining. Lentiviruses were constructed to alter the expression of Mif (macrophage migration inhibitory factor) in Schwann cells. Western blot (WB) analysis was employed to detect the protein expression. The results of this study show that Mif is essential for Schwann cells to promote osteogenesis, and its downstream CD74/FOXO1 is also involved in the promotion of Schwann cells on osteogenesis. Further, Schwann cells regulate amino acid metabolism and lipid metabolism in preosteoblasts. These findings unveil the mechanism for Schwann cells to promote osteogenesis where Mif is a key factor. |
相关链接 | [Scopus记录] |
收录类别 | |
语种 | 英语
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学校署名 | 通讯
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资助项目 | Supporting funds for scientific research of Southern University of Science and Technology[Y01416214]
; NSFCs Youth Program of National Natural Science Foundation of China[81902202]
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WOS研究方向 | Cell Biology
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WOS类目 | Cell & Tissue Engineering
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WOS记录号 | WOS:000772085500001
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出版者 | |
Scopus记录号 | 2-s2.0-85123526580
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来源库 | Scopus
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引用统计 |
被引频次[WOS]:3
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成果类型 | 期刊论文 |
条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/327937 |
专题 | 南方科技大学医院 南方科技大学医学院 |
作者单位 | 1.Department of Orthopaedics,Xijing Hospital,Air Force Medical University,Xi'an,710032,China 2.Southern University of Science and Technology Hospital,Shenzhen,No. 6019 Liuxian Street, Xili Avenue, Nanshan District,518055,China 3.School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China |
第一作者单位 | 南方科技大学医院; 南方科技大学医学院 |
通讯作者单位 | 南方科技大学医院; 南方科技大学医学院 |
推荐引用方式 GB/T 7714 |
Li,Jun Qin,Jiang,Hui Jie,Su,Xiu Yun,et al. Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway in Vitro[J]. Stem Cells International,2022,2022.
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APA |
Li,Jun Qin.,Jiang,Hui Jie.,Su,Xiu Yun.,Feng,Li.,Zhan,Na Zhi.,...&Pei,Guo Xian.(2022).Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway in Vitro.Stem Cells International,2022.
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MLA |
Li,Jun Qin,et al."Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway in Vitro".Stem Cells International 2022(2022).
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条目包含的文件 | 条目无相关文件。 |
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