A Pilot Study of Thermal Effect of Low-intensity Focused Ultrasound on Blood Pressure Modulation

Ji，Ning1,2; Lin，Wan Hua3; Li，Yuanheng2; Chen，Fei3; Xu，Lisheng1; Li，Guanglin2

10.1109/EMBC46164.2021.9630455

2021

43rd Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (IEEE EMBC)

1557-170X

1558-4615

978-1-7281-1180-3

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

5690-5693

NOV 01-05, 2021

null,null,ELECTR NETWORK

345 E 47TH ST, NEW YORK, NY 10017 USA

IEEE

Our recent study showed that low-intensity focused ultrasound stimulation (FUS) of the vagus nerve is capable of lowering blood pressure (BP). However, it remains unknown that what is the underlying mechanisms of BP modulation with FUS. In our preliminary experiments, we noticed that there was temperature elevation accompanied the FUS. Thus, to verify whether the thermal effect of ultrasound contributes in the BP-lowering effect, this study compared the BP response under the FUS (with thermal effect and mechanical effect) and the alternative heating source treatment (AHST) (with thermal effect only) of left vagus nerve. Six Sprague Dawley rats were randomly divided into two groups (FUS, n=3 and AHST, n=3). In vivo temperature measurements were conducted to evaluate the heating performance of the FUS and the AHST. Blood pressure (BP) waveform was continuously recorded from the right common artery and was used for analyzing systolic BP (SBP), diastolic BP (DBP), mean BP (MBP), and heart rate (HR). The results showed that the SBP, DBP, MBP and HR decreased during the 15-min FUS. However, most of the SBP, DBP, MBP and HR increased during the 15-min AHST, which had the approximate temperature elevation of the FUS. Thus, the thermal effect of ultrasound probably does not contribute in the BP-lowering effect induced by low-intensity FUS of the vagus nerve.

blood pressure modulation Low-intensity focused ultrasound stimulation thermal effect vagus nerve

其他

英语

CPCI-S ; EI

China Postdoctoral Science Foundation[#2020M672701];National Natural Science Foundation of China[#61773110];National Natural Science Foundation of China[#61901461];National Natural Science Foundation of China[#81927804];

Engineering

Engineering, Biomedical ; Engineering, Electrical & Electronic

WOS:000760910505069

20220811669976

2-s2.0-85122542182

Scopus

1.Northeastern University,College of Medicine and Biological Information Engineering,Shenyang,110819,China
2.CAS Key Lab of Human-Machine Intelligence-Synergy Systems of Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences (CAS),Shenzhen,518055,China
3.Department of Electrical and Electronic Engineering,Southern University of Science and Technology (SUSTech),Shenzhen,518055,China

Ji，Ning,Lin，Wan Hua,Li，Yuanheng,et al. A Pilot Study of Thermal Effect of Low-intensity Focused Ultrasound on Blood Pressure Modulation[C]. 345 E 47TH ST, NEW YORK, NY 10017 USA:IEEE,2021:5690-5693.