南方科技大学知识苑(SUSTech KC): Prothrombotic state and calcium deficiency in early pregnancy are risk factors for gestational diabetes mellitus: a retrospective cohort study

题名	Prothrombotic state and calcium deficiency in early pregnancy are risk factors for gestational diabetes mellitus: a retrospective cohort study
作者	Liu, Qingyun 1; Wei, Shanshan 2; Wang, Feng 3
通讯作者	Wang, Feng
发表日期	2022-03-01
DOI	10.1080/09513590.2022.2047170
发表期刊	GYNECOLOGICAL ENDOCRINOLOGY 影响因子和分区
ISSN	0951-3590
EISSN	1473-0766
卷号	38 期号:5
摘要	Objectives To investigate whether the prothrombotic state (PTS), calcium deficiency and iron deficiency anemia (IDA) in early pregnancy is associated with the risk of gestational diabetes mellitus (GDM). Methods We conducted a retrospective cohort study, including consecutive pregnant women tested for PTS, calcium deficiency and IDA before 20 weeks' gestation between September 1, 2017 and March 21, 2021. For routine prenatal care, pregnant women underwent a 75-g oral glucose tolerance test (OGTT) to make a GDM diagnosis during 24-28 weeks of gestation. Testing data and relevant clinical information were obtained from Shenzhen Baoan Women's and Children's Hospital. To estimate GDM risk of exposures (PTS, calcium deficiency and IDA) in early pregnancy, we used logistic regression to obtain odds ratio (OR) adjusted for maternal age, parity, family history of diabetes and pre-pregnancy body mass index. Results The cohort included 8396 pregnant women with complete data of exposures and GDM outcomes. Baseline characteristics were not comparable between exposure and control groups. PTS (adjusted OR 2.38, 95% CI 1.61-3.52) or calcium deficiency (adjusted OR 1.23, 95% CI 1.02-1.49) in early pregnancy was independently associated with increased GDM risk after adjusting covariates. There was no significant association between IDA status and GDM risk (adjusted OR 0.86, 95% CI 0.63-1.18). Conclusions PTS and calcium deficiency in early pregnancy may be independent risk factors of GDM. These findings need further validation in well-designed prospective cohorts.
关键词	Gestational diabetes mellitus prothrombotic state calcium deficiency iron deficiency anemia cohort
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一
资助项目	Shenzhen Municipal Government of China[JCYJ20180703093402288] ; China Postdoctoral Science Foundation[2020M683201] ; Guangdong Basic and Applied Basic Research Foundation[2020A1515110116]
WOS研究方向	Endocrinology & Metabolism ; Obstetrics & Gynecology
WOS类目	Endocrinology & Metabolism ; Obstetrics & Gynecology
WOS记录号	WOS:000773870000001
出版者	TAYLOR & FRANCIS LTD
ESI学科分类	CLINICAL MEDICINE
来源库	Web of Science
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/328452
专题	南方科技大学医院
作者单位	1.Southern Univ Sci & Technol Hosp, Dept Prevent & Hlth Care, Shenzhen, Peoples R China 2.Sun Yat Sen Univ, Affiliated Hosp 8, Gastrointestinal Endoscopy Ctr, Shenzhen, Peoples R China 3.Jinan Univ, Shenzhen Baoan Womens & Childrens Hosp, Dept Clin Lab, Shenzhen, Guangdong, Peoples R China
第一作者单位	南方科技大学医院
第一作者的第一单位	南方科技大学医院
推荐引用方式 GB/T 7714	Liu, Qingyun,Wei, Shanshan,Wang, Feng. Prothrombotic state and calcium deficiency in early pregnancy are risk factors for gestational diabetes mellitus: a retrospective cohort study[J]. GYNECOLOGICAL ENDOCRINOLOGY,2022,38(5).
APA	Liu, Qingyun,Wei, Shanshan,&Wang, Feng.(2022).Prothrombotic state and calcium deficiency in early pregnancy are risk factors for gestational diabetes mellitus: a retrospective cohort study.GYNECOLOGICAL ENDOCRINOLOGY,38(5).
MLA	Liu, Qingyun,et al."Prothrombotic state and calcium deficiency in early pregnancy are risk factors for gestational diabetes mellitus: a retrospective cohort study".GYNECOLOGICAL ENDOCRINOLOGY 38.5(2022).