ORIGINAL RES EARCH Value of UGT2B7-161 Single Nucleotide Polymorphism in Predicting the Risk of Cardiotoxicity in HER-2 Positive Breast Cancer Patients Who Underwent Pertuzumab Combined with Trastuzumab PSL

Li, Jian1,2; Luo, Hui1,2; Liu, Ying-Ying1,2; Chen, Li-Xin1,2; Zhu, Mei-Qin3; Deng, Quan-Tong3; Zhu, Dong-Mei1,2,4; Wang, Zi-Mo1,2; Xu, Jin-Feng1,2

2022

10.2147/PGPM.S351718

PHARMACOGENOMICS & PERSONALIZED MEDICINE   影响因子和分区

1178-7066

Objective: To explore the value of uridine diphosphate-glucuronosyltransferase 2B7 (UGT2B7)-161 single nucleotide polymorphism in predicting the occurrence of cardiotoxicity in Chinese human epidermal growth factor 2 (HER-2) positive breast cancer patients who underwent pertuzumab combined with trastuzumab Therapy. Methods: Fifty patients with HER-2 positive breast cancer who planned to receive trastuzumab and pertuzumab therapy for more than four cycles were enrolled in this study, and blood samples were collected. Thirty healthy volunteers of matching ages were selected as the control group. Myocardial parameters such as global work index, global effective work, and global wasted work were measured before treatment (M0) and at the end of four cycles of treatment month three (M3). Blood samples were collected from patients at the M0 stage, and polymorphisms of the UGT2B7-161 gene were detected to evaluate the predictive ability of different gene phenotypes on the myocardial drug toxicity injury. Results: There were 35 myocardial work decreased events among 50 patients. There were 24 (47.3%), 15 (40.8%), and 11 (11.8%) patients carrying UGT2B7-161 CC, CT, and TT genotypes, respectively. The occurrence of myocardial work decreased was decreased in UGT2B7-161 TT and CT genotypes (12.5%) compared with CC genotype (41.7%) with statistical significance (P < 0.001). Multivariate logistic regression model analysis exhibited that UGT2B7-161 genotypes, body mass index, and cardiac troponin I were independent factors influencing the risk of cardiotoxicity. Conclusion: UGT2B7-161 single nucleotide polymorphism is a potential predictive factor for cardiotoxicity in HER-2 positive breast cancer patients receiving trastuzumab and pertuzumab dual-targeted drug therapy.

breast cancer pressure-strain loop human epidermal growth factor 2 cardiotoxicity trastuzumab pertuzumab

SCI

英语

通讯

Sanming Cultivation Project of Medicine in Shenzhen[SYLY201903]

Pharmacology & Pharmacy

Pharmacology & Pharmacy

WOS:000772905200001

DOVE MEDICAL PRESS LTD

Web of Science

1.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Ultrasound, Shenzhen 518020, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 1, Clin Med Coll 2, Jinan Univ,Dept Med Oncol,Shenzhen Peoples Hosp, Shenzhen 518020, Guangdong, Peoples R China
4.North Sichuan Med Coll, Affiliated Nanchong Cent Hosp, Dept Ultrasound, Nanchong, Peoples R China

Li, Jian,Luo, Hui,Liu, Ying-Ying,et al. ORIGINAL RES EARCH Value of UGT2B7-161 Single Nucleotide Polymorphism in Predicting the Risk of Cardiotoxicity in HER-2 Positive Breast Cancer Patients Who Underwent Pertuzumab Combined with Trastuzumab PSL[J]. PHARMACOGENOMICS & PERSONALIZED MEDICINE,2022,15.

Li, Jian.,Luo, Hui.,Liu, Ying-Ying.,Chen, Li-Xin.,Zhu, Mei-Qin.,...&Xu, Jin-Feng.(2022).ORIGINAL RES EARCH Value of UGT2B7-161 Single Nucleotide Polymorphism in Predicting the Risk of Cardiotoxicity in HER-2 Positive Breast Cancer Patients Who Underwent Pertuzumab Combined with Trastuzumab PSL.PHARMACOGENOMICS & PERSONALIZED MEDICINE,15.

Li, Jian,et al."ORIGINAL RES EARCH Value of UGT2B7-161 Single Nucleotide Polymorphism in Predicting the Risk of Cardiotoxicity in HER-2 Positive Breast Cancer Patients Who Underwent Pertuzumab Combined with Trastuzumab PSL".PHARMACOGENOMICS & PERSONALIZED MEDICINE 15(2022).