南方科技大学知识苑(SUSTech KC): Microparticle Transport and Sedimentation in a Rhythmically Expanding Alveolar Chip

题名	Microparticle Transport and Sedimentation in a Rhythmically Expanding Alveolar Chip
作者	Zhang, Wei 1; Dong, Jun 1; Lv, Huimin 1; Bai, Weitao 1; Lu, Hongzhou 2; Noack, Bernd R.1; Zhu, Yonggang 1; Yang, Yue 1
通讯作者	Yang, Yue
发表日期	2022-03-01
DOI	10.3390/mi13030485
发表期刊	MICROMACHINES 影响因子和分区
EISSN	2072-666X
卷号	13 期号:3
摘要	Understanding the mechanism of particle transport and sedimentation in pulmonary alveolus is important for deciphering the causes of respiratory diseases and helping the development of drug delivery. In this study, taking advantage of the microfluidic technique, an experimental platform was developed to study particle behavior in a rhythmically expanding alveolar chip for a sufficient number of cycles. The alveolar flow patterns at different generations were measured for two cases with the gravity direction parallel or vertical to the alveolar duct. Affected by both the vortex flow inside the alveoli and the shear flow in the duct simultaneously, it was observed that particles inside the alveoli either escaped from the inlet of the alveolar duct or stayed in the alveoli, revealing the irreversibility of particle transport in the alveoli. At the earlier acinar generations, particles were inclined to deposit on the distal alveolar wall. The settling rates of particles of different sizes in the alveoli were also compared. This study provides valuable data for understanding particle transport and sedimentation in the alveoli.
关键词	alveolar chip particle tracking microfluidics dynamical similarity particle deposition
相关链接	[来源记录]
收录类别	SCI ; EI
语种	英语
学校署名	其他
资助项目	National Natural Science Foundation of China[11772112] ; Guangdong Basic and Applied Basic Research Foundation[2019B1515120037]
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Instruments & Instrumentation ; Physics
WOS类目	Chemistry, Analytical ; Nanoscience & Nanotechnology ; Instruments & Instrumentation ; Physics, Applied
WOS记录号	WOS:000774073500001
出版者	MDPI
来源库	Web of Science
引用统计	被引频次[WOS]：4
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/328455
专题	南方科技大学第二附属医院
作者单位	1.Harbin Inst Technol, Sch Mech Engn & Automat, Shenzhen 518055, Peoples R China 2.Southern Univ Sci & Technol, Natl Clin Res Ctr Infect Dis, Peoples Hosp Shenzhen 3, Affiliated Hosp 2, Shenzhen 518112, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Wei,Dong, Jun,Lv, Huimin,et al. Microparticle Transport and Sedimentation in a Rhythmically Expanding Alveolar Chip[J]. MICROMACHINES,2022,13(3).
APA	Zhang, Wei.,Dong, Jun.,Lv, Huimin.,Bai, Weitao.,Lu, Hongzhou.,...&Yang, Yue.(2022).Microparticle Transport and Sedimentation in a Rhythmically Expanding Alveolar Chip.MICROMACHINES,13(3).
MLA	Zhang, Wei,et al."Microparticle Transport and Sedimentation in a Rhythmically Expanding Alveolar Chip".MICROMACHINES 13.3(2022).