A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity

Wang, Xin1,2,3; Yin, Xiaochen1; Zhang, Boya1; Liu, Chenfeng5; Lin, Yahua1; Huang, Xiaofen1; Li, Yufang1; Shen, Chenguang1; Zheng, Weibin4; Fu, Guofeng4; Chen, Junyu1; Wen, Yanling2,3; Zhang, Wei1; Pan, Bo-Sheng7; Fang, Mujin1; Zheng, Zizheng1; Zhang, Zheng2,3; Yuan, Quan1; Fu, Guo4; Li, Shaowei1; Zhang, Jun1; Chen, Yixin1; Xia, Ningshao1; Zhao, Qinjian1,6

2022-12-31

10.1080/22221751.2022.2050951

EMERGING MICROBES & INFECTIONS   影响因子和分区

2222-1751

Infection caused by respiratory viruses can lead to a severe respiratory disease and even death. Vaccination is the most effective way to prevent the disease, but it cannot be quickly applied when facing an emerging infectious disease. Here, we demonstrated that immunization with an aluminium-zinc hybrid particulate adjuvant (FH-001) alone, bearing great resemblance in morphology with commonly used aluminium-based adjuvants in vaccines, could quickly induce mice to generate a broadly protective immune response to resist the lethal challenge of influenza B viruses. Furthermore, a multi-omics-based analysis revealed that the alveolar macrophage and type I interferon pathway, rather than adaptive immunity and type II interferon pathway, were essential for the observed prophylactic effect of FH-001. More importantly, a similar protective effect was observed against influenza A virus strain A/Shanghai/02/2013(H7N9), A/California/04/2009(H1N1) and respiratory syncytial virus. Therefore, we introduced here a new and promising strategy that can be quickly applied during the outbreak of emerging respiratory viruses.

Prophylactic influenza respiratory syncytial virus alveolar macrophage interferon

SCI

英语

通讯

National Natural Science Foundation of China[32070925,82041038] ; National Key Research and Development Programs of China[2020YFC0842600] ; Guangdong Provincial Department of Science and Technology[2020B1111340033]

Immunology ; Infectious Diseases ; Microbiology

Immunology ; Infectious Diseases ; Microbiology

WOS:000773723600001

TAYLOR & FRANCIS LTD

Web of Science

1.Xiamen Univ, Sch Publ Hlth, Natl Inst Diagnost & Vaccine Dev Infect Dis, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen, Peoples R China
2.Southern Univ Sci & Technol, Natl Clin Res Ctr Infect Dis, Inst Hepatol, Shenzhen Peoples Hosp 3, Shenzhen, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 2, Sch Med, Shenzhen, Peoples R China
4.Xiamen Univ, Sch Life Sci, Xiamen, Peoples R China
5.Anhui Med Univ, Sch Life Sci, Dept Cell Biol, Hefei, Peoples R China
6.Chongqing Med Univ, Coll Pharm, Chongqing, Peoples R China
7.Reverie Labs, Cambridge, MA USA

Wang, Xin,Yin, Xiaochen,Zhang, Boya,et al. A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity[J]. EMERGING MICROBES & INFECTIONS,2022,11(1).

Wang, Xin.,Yin, Xiaochen.,Zhang, Boya.,Liu, Chenfeng.,Lin, Yahua.,...&Zhao, Qinjian.(2022).A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity.EMERGING MICROBES & INFECTIONS,11(1).

Wang, Xin,et al."A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity".EMERGING MICROBES & INFECTIONS 11.1(2022).