南方科技大学知识苑(SUSTech KC): New advances in gated materials of mesoporous silica for drug controlled release

题名	New advances in gated materials of mesoporous silica for drug controlled release
作者	Huang, Ping 1; Lian, Daizheng 2,3; Ma, Hualin 2,3; Gao, Nansha 1; Zhao, Limin 4; Luan, Ping 5; Zeng, Xiaowei 1
通讯作者	Ma, Hualin; Zhao, Limin; Zeng, Xiaowei
发表日期	2021-12-01
DOI	10.1016/j.cclet.2021.06.034
发表期刊	CHINESE CHEMICAL LETTERS 影响因子和分区
ISSN	1001-8417
EISSN	1878-5964
卷号	32 期号:12
摘要	Drug delivery systems (DDS) are used to deliver therapeutic drugs to improve selectivity and reduce side effects. With the development of nanotechnology, many nanocarriers have been developed and applied to drug delivery, including mesoporous silica. Mesoporous silica nanoparticles (MSNs) have attracted a lot of attention for simple synthesis, biocompatibility, high surface area and pore volume. Based on the pore system and surface modification, gated mesoporous silica nanoparticles can be designed to realize on-command drug release, which provides a new approach for selective delivery of antitumor drugs. Herein, this review mainly focuses on the "gate keepers" of mesoporous silica for drug controlled release in nearly few years (2017-2020). We summarize the mechanism of drug controlled release in gated MSNs and different gated materials: inorganic gated materials, organic gated materials, self-gated drug molecules, and biological membranes. The facing challenges and future prospects of gated MSNs are discussed rationally in the end. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
关键词	Mesoporous silica Gated materials Surface modification Drug delivery Controlled release
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	National Natural Science Foundation of China[32071342] ; Guangdong Special Support Program[2019TQ05Y209] ; Natural Science Foundation of Guangdong Province[2021A1515010431] ; Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties[SZGSP001] ; Shenzhen Key Laboratory of Kindey Diseases[ZDSYS201504301616234] ; Key Project of Basic Research of Shenzhen[JCYJ20200109113603854] ; International Cooperation Research Project of Shenzhen[GJHZ20180418190557102]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000771784000005
出版者	ELSEVIER SCIENCE INC
ESI学科分类	CHEMISTRY
来源库	Web of Science
引用统计	被引频次[WOS]：65
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/328462
专题	南方科技大学第一附属医院
作者单位	1.Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Inst Pharmaceut, Shenzhen 518107, Peoples R China 2.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1,Shenzhen Key Lab Kidney Dis, Shenzhen Peoples Hosp,Clin Med Coll 2,Dept Nephro, Shenzhen 518020, Peoples R China 3.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp,Clin Med Coll 2,Dept Radiat, Shenzhen 518020, Peoples R China 4.Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Guangzhou 510000, Peoples R China 5.Shenzhen Univ, Hlth Sci Ctr, Shenzhen 518060, Peoples R China
通讯作者单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Huang, Ping,Lian, Daizheng,Ma, Hualin,et al. New advances in gated materials of mesoporous silica for drug controlled release[J]. CHINESE CHEMICAL LETTERS,2021,32(12).
APA	Huang, Ping.,Lian, Daizheng.,Ma, Hualin.,Gao, Nansha.,Zhao, Limin.,...&Zeng, Xiaowei.(2021).New advances in gated materials of mesoporous silica for drug controlled release.CHINESE CHEMICAL LETTERS,32(12).
MLA	Huang, Ping,et al."New advances in gated materials of mesoporous silica for drug controlled release".CHINESE CHEMICAL LETTERS 32.12(2021).