Detection of Kidney Dysfunction through in Vivo Magnetic Resonance Imaging with Renal-Clearable Gadolinium Nanoprobes

Wang，Jun1; Zha，Menglei1; Zhao，Hui2; Yue，Wentong1; Wu，Decheng1; Li，Kai1

2022-03-08

10.1021/acs.analchem.1c05140

ANALYTICAL CHEMISTRY   影响因子和分区

0003-2700

1520-6882

Kidney dysfunction is a clinical syndrome that can subsequently result in lethal kidney failure. The exploration of emerging bioimaging contrast agents with translational potential is highly challenging for a feasible diagnosis of kidney dysfunction. Herein, a class of renal-clearable gadolinium nanoparticles (Gd@PEG NPs) with an ultrasmall size of ∼5 nm, good monodispersity, and T1 relaxivity are synthesized using mesoporous silica nanoparticles as the template. Assisted by such renal-clearable Gd@PEG NPs, the diagnosis of kidney dysfunction in a mice model with a damaged kidney has been achieved through in vivo noninvasive magnetic resonance imaging. As a result, this work paves the way to synthesize monodispersible ultrasmall Gd contrast agents, facilitating the exploration of translational strategies for an in vivo analysis of kidney dysfunction.

SCI ; EI

英语

NI论文

第一 ; 通讯

Ministry of Science and Technology of China[2020YFA0908900] ; National Natural Science Foundation of China[U21A2097] ; Department of Science and Technology of Guangdong Province["2019ZT08Y191","2019QN01Y640"] ; Shenzhen Key Laboratory of Smart Healthcare Engineering[ZDSYS20200811144003009] ; Shenzhen Science and Technology Program[KQTD20190929172743294]

Chemistry

Chemistry, Analytical

WOS:000819810300031

AMER CHEMICAL SOC

20221011748429

Gadolinium ; Mammals ; Nanomagnetics ; Silica nanoparticles ; Synthesis (chemical)

Rare Earth Metals:547.2 ; Magnetism: Basic Concepts and Phenomena:701.2 ; Imaging Techniques:746 ; Nanotechnology:761 ; Chemical Reactions:802.2

CHEMISTRY

2-s2.0-85125674609

Scopus

1.Shenzhen Key Laboratory of Smart Healthcare Engineering,Department of Biomedical Engineering,Southern University of Science and Technology (SUSTech),Shenzhen,518055,China
2.Department of Mri Diagnosis,The Second Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang,150086,China

Wang，Jun,Zha，Menglei,Zhao，Hui,et al. Detection of Kidney Dysfunction through in Vivo Magnetic Resonance Imaging with Renal-Clearable Gadolinium Nanoprobes[J]. ANALYTICAL CHEMISTRY,2022,94(9):4005-4011.

Wang，Jun,Zha，Menglei,Zhao，Hui,Yue，Wentong,Wu，Decheng,&Li，Kai.(2022).Detection of Kidney Dysfunction through in Vivo Magnetic Resonance Imaging with Renal-Clearable Gadolinium Nanoprobes.ANALYTICAL CHEMISTRY,94(9),4005-4011.

Wang，Jun,et al."Detection of Kidney Dysfunction through in Vivo Magnetic Resonance Imaging with Renal-Clearable Gadolinium Nanoprobes".ANALYTICAL CHEMISTRY 94.9(2022):4005-4011.