南方科技大学知识苑(SUSTech KC): Exosomal circSHKBP1 participates in non-small cell lung cancer progression through PKM2-mediated glycolysis

题名	Exosomal circSHKBP1 participates in non-small cell lung cancer progression through PKM2-mediated glycolysis
作者	Chen, Wenbiao 1; Tang, Donge 2; Lin, Junqi 1; Huang, Xiaoming 1; Lin, Shaoming 1; Shen, Guanle 1; Dai, Yong 2
通讯作者	Shen, Guanle; Dai, Yong
发表日期	2022-03-17
DOI	10.1016/j.omto.2022.01.012
发表期刊	Molecular Therapy-Oncolytics 影响因子和分区
ISSN	2372-7705
卷号	24
摘要	Non-small cell lung cancer (NSCLC) has a high morbidity and mortality, and it is imperative to explore the latent pathogenesis mechanism of NSCLC progression to find potential prognostic biomarkers and therapeutic targets. The present study aimed to explore the biological function of circSHKBP1 in NSCLC. circSHKBP1 was found to be upregulated in NSCLC tissues and cell lines and was enriched in exosomes derived from NSCLC cells. Exosomal circSHKBP1 enhanced the proliferation, migration, invasion, and stemness of NSCLC cells. miRNA-1294 was identified as a target for circSHKBP1, and circSHKBP1 upregulated PKM2 expression by sponging miR-1294. Exosomal circSHKBP1 regulated glycolysis through PKM2 in a HIF-1 alpha-dependent manner in NSCLC cells and promoted M2 polarization and macrophage recruitment. Moreover, exosomal circSHKBP1 promoted NSCLC cell growth, metastasis, and M2 infiltration in vivo. Thus, exosomal circSHKBP1 participated in the progression of NSCLC via the miR-1294/PKM2 axis. circSHKBP1 may be potential biomarker for the diagnosis and treatment of NSCLC.
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	China Postdoctoral Foundation[2021M703372] ; Basic and Applied Basic Research Fund of Guangdong Province[2021A1515110967] ; National Natural Science Foundation of China[82003172]
WOS研究方向	Oncology ; Research & Experimental Medicine
WOS类目	Oncology ; Medicine, Research & Experimental
WOS记录号	WOS:000773340200001
出版者	CELL PRESS
来源库	Web of Science
引用统计	被引频次[WOS]：31
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/328746
专题	南方科技大学第一附属医院
作者单位	1.Southern Med Univ, Peoples Hosp Longhua, Dept Resp Med, Affiliated Hosp, Jianshe East Rd, Shenzhen 518109, Peoples R China 2.Southern Univ Sci & Technol, Shenzhen Peoples Hosp,Affiliated Hosp 1, Guangdong Prov Engn Res Ctr Autoimmune Dis Precis, Clin Med Res Ctr,Jinan Univ,Clin Med Coll 2, 1017 Dongmen North Rd, Shenzhen 518020, Peoples R China
通讯作者单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Chen, Wenbiao,Tang, Donge,Lin, Junqi,et al. Exosomal circSHKBP1 participates in non-small cell lung cancer progression through PKM2-mediated glycolysis[J]. Molecular Therapy-Oncolytics,2022,24.
APA	Chen, Wenbiao.,Tang, Donge.,Lin, Junqi.,Huang, Xiaoming.,Lin, Shaoming.,...&Dai, Yong.(2022).Exosomal circSHKBP1 participates in non-small cell lung cancer progression through PKM2-mediated glycolysis.Molecular Therapy-Oncolytics,24.
MLA	Chen, Wenbiao,et al."Exosomal circSHKBP1 participates in non-small cell lung cancer progression through PKM2-mediated glycolysis".Molecular Therapy-Oncolytics 24(2022).