Metabolic Syndrome Components and Chronic Kidney Disease in a Community Population Aged 40 Years and Older in Southern China: A Cross-Sectional Study

Xiao, Hua1,2; Shao, Xiaofei3; Gao, Peichun4; Zou, Hequn5; Zhang, Xinzhou1

2022

10.2147/DMSO.S353305

Diabetes Metabolic Syndrome and Obesity-Targets and Therapy   影响因子和分区

1178-7007

Purpose: To investigate the correlation between metabolic syndrome components and chronic kidney disease (CKD) among a community population aged 40 years and older in Southern China. Patients and Methods: From December 2017 to March 2018, 1969 participants (male n = 715, female n = 1254) aged 40 years and older were recruited in Southern China for a cross-sectional survey. A logistic regression model was established to analyze the correlation between metabolic syndrome components and CKD. Results: Among the 1969 subjects, 407 (20.7%) were CKD patients, including 152 males (prevalence rate 21.3%) and 255 females (prevalence rate 20.3%). Anthropometric data (waist circumference, age, systolic and diastolic blood pressure), serum/plasma data (serum creatinine, serum uric acid, fasting plasma glucose, C-reactive protein, serum triglyceride), urinary and other findings (body mass index, waist-to-hip and waist-to-height ratios, urinary albumin to creatinine ratio, homeostasis model assessment of insulin resistance) were significantly higher in patients with than without CKD (P < 0.05). Metabolic syndrome and at least some of its components were statistically significant risk factors for CKD in models with and without adjustment for diabetes, obesity and hypertension. Conclusion: Metabolic syndrome and its single or combined components are independently associated with CKD in community populations aged 40 years and older. The correlation between some components and CKD remained significant in both non-diabetic and non-obese subjects. Correlations between components of metabolic syndrome and CKD show that it is feasible and necessary to carry out targeted screening and intervention tests in people aged 40 and over.

metabolic syndrome chronic kidney disease risk factors epidemiological cross-sectional study

SCI

英语

第一 ; 通讯

Risk factors and prediction model of chronic kidney disease caused by metabolic syndrome: A multicentric prospective cohort study Clinical trial training project of Southern Medical University[LC2016PY047] ; Science and Technique Program of Guangzhou[201604020015] ; South Wisdom Valley Innovative Research Team Program[CXTD-004] ; Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties[SZGSP001] ; Shenzhen Governmental Sustainable Development Fund[KCXFZ20201221173612034]

Endocrinology & Metabolism

Endocrinology & Metabolism

WOS:000773345600004

DOVE MEDICAL PRESS LTD

Web of Science

1.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Dept Nephrol,Affiliated Hosp 1,Clin Med Coll 2, Shenzhen 518020, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Jinan Univ, Clin Med Coll 2,Shenzhen Peoples Hosp,Shenzhen Ke, Shenzhen 518055, Peoples R China
3.Southern Med Univ, Dept Nephrol, Affiliated Hosp 3, Guangzhou 510630, Peoples R China
4.Southern Med Univ, Zhujiang Hosp, Guangzhou 510282, Peoples R China
5.Shenzhen Univ, South China Hosp, Hlth Sci Ctr, Dept Nephrol, Shenzhen 518116, Peoples R China

Xiao, Hua,Shao, Xiaofei,Gao, Peichun,et al. Metabolic Syndrome Components and Chronic Kidney Disease in a Community Population Aged 40 Years and Older in Southern China: A Cross-Sectional Study[J]. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy,2022,15.

Xiao, Hua,Shao, Xiaofei,Gao, Peichun,Zou, Hequn,&Zhang, Xinzhou.(2022).Metabolic Syndrome Components and Chronic Kidney Disease in a Community Population Aged 40 Years and Older in Southern China: A Cross-Sectional Study.Diabetes Metabolic Syndrome and Obesity-Targets and Therapy,15.

Xiao, Hua,et al."Metabolic Syndrome Components and Chronic Kidney Disease in a Community Population Aged 40 Years and Older in Southern China: A Cross-Sectional Study".Diabetes Metabolic Syndrome and Obesity-Targets and Therapy 15(2022).