Ultrasound score combined with liver stiffness measurement by sound touch elastography for staging liver fibrosis in patients with chronic hepatitis B: a clinical prospective study

Huang, Kun1; Li, Qinyuan2; Zeng, Weimei3; Chen, Xin4; Liu, Li5; Wan, Xiang5; Feng, Cheng1; Li, Zhiyan1; Liu, Zhong4; Dong, Changfeng1

2022-03-01

10.21037/atm-22-505

Annals of Translational Medicine   影响因子和分区

2305-5839

2305-5847

["Background: A noninvasive and precise diagnosis of liver fibrosis in patients with chronic hepatitis B (CHB) is crucial for establishing the optimal time and strategy of therapy and for predicting treatment response. This study aimed to assess the diagnostic performance of ultrasound (US) score and liver stiffness measurement (LSM) of sound touch elastography (STE) in diagnosing liver fibrosis stages and to investigate whether combining these methods would improve liver fibrosis staging.","Methods: US and STE examinations were performed in CHB patients included. Liver biopsy was used as a reference standard. A diagnostic marker with the optimal linear combination (LC) of US score and LSM of STE, namely LC marker, was established for noninvasive assessment of liver fibrosis stages. The diagnostic performance of the LC marker was evaluated by using receiver operating characteristic (ROC) curves and the area under the ROC curve (AUC).","Results: A total of 291 subjects, including 242 patients with CHB and 49 healthy volunteers, were included. Correlation analysis showed that the correlation of liver fibrosis stages to the LC marker (Spearman's r=0.846, P<0.001) was higher than that of LSM (r=0.771, P<0.001) or US score (r=0.825, P<0.001) alone. The results showed that the overall diagnostic performance of the LC marker in predicting a fibrosis stage of >= F1, >= F2, >= F3 and =F4 {AUCs: 0.943 [95% confidence interval (CI): 0.917-0.948], 0.906 (0.871-0.915), 0.953 (0.923-0.969), and 0.961 (0.922-0.973), respectively} were better than those of the US score [AUCs: 0.916 (0.883-0.948, P=0.014), 0.875 (0.835-0.915, P<0.001), 0.934 (0.898-0.969, P=0.001), and 0.918 (0.864-0.973, P<0.001), respectively] or LSM [AUCs: 0.858 (0.812-0.948, P<0.001), 0.867 (0.826-0.915, P=0.006), 0.930 (0.894-0.969, P<0.023), and 0.958 (0.918-0.973, P=0.778), respectively].","Conclusions: The LC marker with the optimal combination of LSM and US score may be considered as a promising diagnostic model for noninvasive staging of liver fibrosis."]

Ultrasound sound touch elastography (STE) liver stiffness measurement (LSM) chronic hepatitis B (CHB) liver fibrosis staging

SCI

英语

第一 ; 通讯

National Natural Science Foundation of China[82172563,81871429,61901282] ; Key-Area Research and Development Program of Guangdong Province[2020B1111130002] ; clinical research project of Shenzhen Third People's Hospital[G2022018]

Oncology ; Research & Experimental Medicine

Oncology ; Medicine, Research & Experimental

WOS:000773671700001

AME PUBL CO

Web of Science

1.Southern Univ Sci & Technol, Natl Clin Res Ctr Infect Dis, Dept Ultrasound, Shenzhen Peoples Hosp 3,Hosp 2, Shenzhen, Peoples R China
2.Guangdong Med Univ, Ultrasound Imaging Dept, Affiliated Hosp, Zhanjiang, Peoples R China
3.Guangdong Med Univ, Med Coll 1, Zhanjiang, Peoples R China
4.Shenzhen Univ, Sch Biomed Engn, Natl Reg Key Technol Engn Lab Med Ultrasound, Guangdong Key Lab Biomed Measurements & Ultrasoun, 1066 Xueyuan Rd, Shenzhen 518000, Peoples R China
5.Chinese Univ Hong Kong, Shenzhen Res Inst Big Data, Shenzhen, Peoples R China

Huang, Kun,Li, Qinyuan,Zeng, Weimei,et al. Ultrasound score combined with liver stiffness measurement by sound touch elastography for staging liver fibrosis in patients with chronic hepatitis B: a clinical prospective study[J]. Annals of Translational Medicine,2022.

Huang, Kun.,Li, Qinyuan.,Zeng, Weimei.,Chen, Xin.,Liu, Li.,...&Dong, Changfeng.(2022).Ultrasound score combined with liver stiffness measurement by sound touch elastography for staging liver fibrosis in patients with chronic hepatitis B: a clinical prospective study.Annals of Translational Medicine.

Huang, Kun,et al."Ultrasound score combined with liver stiffness measurement by sound touch elastography for staging liver fibrosis in patients with chronic hepatitis B: a clinical prospective study".Annals of Translational Medicine (2022).