Early detect left ventricular subclinical myocardial dysfunction in patients with systemic lupus erythematosus by a left ventricular pressure-strain loop

Zhong, Xiao-Fang1; Chen, Li-Xin1; Liu, Li-Xiong2; Peng, Gui-Juan1; Luo, Shu-Yu1; Liu, Dong-Sheng3; Xu, Jin-Feng1; Liu, Ying-Ying1

2022-03-01

10.1177/09612033221089150

LUPUS   影响因子和分区

0961-2033

1477-0962

Objective Noninvasive myocardial work (MW) is a new technology which is based on strain after considering the load influence on myocardial deformation. We aimed to investigate the feasibility of quantitatively assessing left ventricular myocardial work (LVMW) in patients with systemic lupus erythematosus (SLE) using a left ventricular pressure-strain loop (LVPSL). Methods 76 patients with SLE were included in the study (A), further divided into two subgroups according to the presence of lupus nephritis (LN). Global longitudinal strain (GLS), peak strain dispersion (PSD), global myocardial work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE) were obtained. Results 1: Patients with SLE demonstrated a significantly reduced GWE and GLS compared with control group, GWW and PSD were increased, above changes were more pronounced in patients with LN. There was no significant difference in GWI and GCW. 2: Receiver operating characteristic (ROC) analysis demonstrated that GWE was the most powerful tool for detecting myocardial insufficiency early in SLE patients, and the area under the curve (AUC) was 0.804, and was superior to GLS (AUC = 0.707). GWE remains the best indicator of subclinical myocardial injury in patients with LN. The AUC was 0.910, and the best cutoff point was 96.5% (sensitivity 83.3%, specificity 73.3%). Conclusions LVPSL can be used to noninvasively assess changes in MW in patients with SLE. Noninvasive GWE is a more sensitive index than GLS to detect subclinical myocardial injury early in SLE patients. This is a potential valuable clinical tool to assist in the early-find myocardial damage.

myocardial work lupus nephritis systemic lupus erythematosus speckle tracking echocardiography

SCI

英语

第一 ; 通讯

National Natural Science Foundation of China[81771841] ; Project of Innovation of the Science and Technology Commission of Shenzhen City[JCYJ20190807145609482]

Rheumatology

Rheumatology

WOS:000777565900001

SAGE PUBLICATIONS LTD

CLINICAL MEDICINE

Web of Science

1.Southern Univ Sci & Technol, Dept Ultrasound, Affiliated Hosp 1,Shenzhen Med Ultrasound Engn Ct, Shenzhen Peoples Hosp,Clin Med Coll 2,Jinan Univ, Shenzhen, Peoples R China
2.Southern Univ Sci & Technol, Dept Rheumatol, Affiliated Hosp 1, Shenzhen Peoples Hosp,Clin Med Coll 2,Jinan Univ, Shenzhen, Peoples R China
3.Peking Univ, Dept Pain Management, Shenzhen Hosp, Shenzhen, Peoples R China

Zhong, Xiao-Fang,Chen, Li-Xin,Liu, Li-Xiong,et al. Early detect left ventricular subclinical myocardial dysfunction in patients with systemic lupus erythematosus by a left ventricular pressure-strain loop[J]. LUPUS,2022,31(5).

Zhong, Xiao-Fang.,Chen, Li-Xin.,Liu, Li-Xiong.,Peng, Gui-Juan.,Luo, Shu-Yu.,...&Liu, Ying-Ying.(2022).Early detect left ventricular subclinical myocardial dysfunction in patients with systemic lupus erythematosus by a left ventricular pressure-strain loop.LUPUS,31(5).

Zhong, Xiao-Fang,et al."Early detect left ventricular subclinical myocardial dysfunction in patients with systemic lupus erythematosus by a left ventricular pressure-strain loop".LUPUS 31.5(2022).