Cellular organelle-targeted smart AIEgens in tumor detection, imaging and therapeutics

Hong Luo，Guang1,2; Zhao Xu，Tian1; Li，Xing2; Jiang，Wei7; Hong Duo，Yan1,3,4,6; Zhong Tang，Ben5

2022-07-01

10.1016/j.ccr.2022.214508

COORDINATION CHEMISTRY REVIEWS   影响因子和分区

0010-8545

The cell contains various organelles that perform different functions using different biological processes to form a complete organic architecture. Healthy cells and tumor cells often show clear differences in cellular homeostasis. Specific detection, imaging, and therapeutic strategies targeting organelles have been found to be effective for tumor diagnosis and therapy. The multiple functions of AIEgens make them attractive over other nanomaterials, and the application of AIEgens has increased dramatically in tumor-related nanomedicine, specifically, for the detection, bioimaging, and therapy of cancers. Here, recent advances in AIEgen applications targeting specific organelles are summarized. The ability of AIEgens to target specific organelles has enhanced various diagnostic and therapeutic applications of this technology, and this review will provide guidance for further exploration in AIEgen-related nanomedicine.

AIEgens Detection Imaging Organelle Therapy

英语

第一 ; 通讯

CHEMISTRY

2-s2.0-85127163925

Scopus

1.Department of Radiation Oncology,Shenzhen People's Hospital (The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,Guangdong,518020,China
2.School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China
3.Department of Medical Epidemiology and Biostatistics,Karolinska Institutet,Stockholm,17177,Sweden
4.Key Lab for New Drug Research of TCM,Research Institute of Tsinghua University in Shenzhen,Shenzhen,Guangdong,518057,China
5.Shenzhen Institute of Aggregate Science and Technology,School of Science and Engineering,The Chinese University of Hong Kong,Shenzhen,Guangdong,518172,China
6.Department of Sports Medicine and Rehabilitation,Peking University Shenzhen Hospital,Shenzhen,Guangdong,518036,China
7.Academy of Medical Science,Zhengzhou University,Zhengzhou,450052,China

Hong Luo，Guang,Zhao Xu，Tian,Li，Xing,et al. Cellular organelle-targeted smart AIEgens in tumor detection, imaging and therapeutics[J]. COORDINATION CHEMISTRY REVIEWS,2022,462.

Hong Luo，Guang,Zhao Xu，Tian,Li，Xing,Jiang，Wei,Hong Duo，Yan,&Zhong Tang，Ben.(2022).Cellular organelle-targeted smart AIEgens in tumor detection, imaging and therapeutics.COORDINATION CHEMISTRY REVIEWS,462.

Hong Luo，Guang,et al."Cellular organelle-targeted smart AIEgens in tumor detection, imaging and therapeutics".COORDINATION CHEMISTRY REVIEWS 462(2022).