The value of radiomic features in chronic obstructive pulmonary disease assessment: a prospective study

Yang，K.1,2; Yang，Y.3; Kang，Y.4,5; Liang，Z.3; Wang，F.3; Li，Q.4; Xu，J.3; Tang，G.3; Chen，R.1

2022

10.1016/j.crad.2022.02.015

CLINICAL RADIOLOGY   影响因子和分区

0009-9260

1365-229X

AIM: To investigate whether radiomic features could supply additional information in the assessment of lung function, health status, and exacerbation of chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: This prospective study enrolled 197 patients who underwent high-resolution chest computed tomography (CT) between 2009 and 2011. A total of 17 radiomic features from chest CT images were selected to explore the applicability of radiomics in the evaluation of COPD. Spirometric lung function testing, modified Medical Research Council (mMRC), St George's respiratory questionnaire (SGRQ), 6-minute walk test (6MWT), and exacerbations were collected at baseline and 1-year follow-up. The relationships of radiomic features, lung function, health status, and exacerbation were assessed using linear and logistic multivariate analyses. RESULTS: At baseline visit, radiomic features were significantly associated with forced expiratory volume in 1 second percent of predicted (FEV % predicted), FEV/forced vital capacity (FVC), mMRC, and SGRQ after multivariate adjustment. At 1-year follow-up, original_10percentile was associated with mMRC change, and original_10percentile, original_elongation, original_sphericity, and original_glv were associated with SGRQ change. Original_flatness was associated with exacerbation and can improve the prediction performance of other models for exacerbation. No radiomic features correlated with the 6MWT. CONCLUSION: Radiomic features were associated with airflow obstruction, health status, and exacerbation of COPD independent of other factors, showing promise in the assessment of COPD.

SCI

英语

第一 ; 通讯

China Postdoctoral Science Foundation[2020M673082];China Postdoctoral Science Foundation[2021M691243];National Natural Science Foundation of China[82100023];National Natural Science Foundation of China[82103941];National Natural Science Foundation of China[82170042];

Radiology, Nuclear Medicine & Medical Imaging

Radiology, Nuclear Medicine & Medical Imaging

WOS:000798524500016

W B SAUNDERS CO LTD

CLINICAL MEDICINE

2-s2.0-85127338302

Scopus

1.Shenzhen Institute of Respiratory Diseases,Shenzhen People's Hospital (the Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,518001,China
2.National Clinical Research Center for Infectious Disease,Shenzhen Third People's Hospital (the Second Affiliated Hospital,Southern University of Science and Technology),Shenzhen,518112,China
3.State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou,510120,China
4.College of Medicine and Biological Information Engineering,Northeastern University,Shenyang,110169,China
5.Medical Device Innovation Center,Shenzhen Technology University,Shenzhen,518001,China

Yang，K.,Yang，Y.,Kang，Y.,et al. The value of radiomic features in chronic obstructive pulmonary disease assessment: a prospective study[J]. CLINICAL RADIOLOGY,2022,77(6).

Yang，K..,Yang，Y..,Kang，Y..,Liang，Z..,Wang，F..,...&Chen，R..(2022).The value of radiomic features in chronic obstructive pulmonary disease assessment: a prospective study.CLINICAL RADIOLOGY,77(6).

Yang，K.,et al."The value of radiomic features in chronic obstructive pulmonary disease assessment: a prospective study".CLINICAL RADIOLOGY 77.6(2022).