A Multifunctional Photoacoustic/Fluorescence Dual-Mode-Imaging Gold-Based Theranostic Nanoformulation without External Laser Limitations

Zhang, Junfeng1,2,3; Yin, Xiaofeng2,3; Li, Chenchen1,2,3; Yin, Xuelian2,3; Xue, Qianghua2,3; Ding, Lin4; Ju, Jiale2,3; Ma, Jifei5; Zhu, Ying5; Du, Dongshu6; Reis, Rui L.2,3,7; Wang, Yanli1,2,3

2022-04-01

10.1002/adma.202110690

ADVANCED MATERIALS   影响因子和分区

0935-9648

1521-4095

Theranostics is a new type of biomedical technology that organically combines the diagnosis and therapy of diseases. Among molecular imaging techniques, the integration of photoacoustic (PA) and fluorescence (FL) imaging modes with high sensitivity and imaging depth provides precise diagnostic outcomes. Gold nanorods (Au NRs) are well-known contrast agents for PA imaging and photothermal therapy. However, their high toxicity, poor biocompatibility, rapid clearance, and the need for an external laser source limit their application. Therefore, modification of Au NRs with carbon-based nanomaterials (CBNs) is done to obtain a multifunctional dual-mode gold-based nanoformulation (mdGC), which preforms dual-mode imaging of PA and FL. The results show that mdGC promotes tumor cell apoptosis and exhibits good antitumor performance through the mitochondria-mediated apoptotic pathway by increasing the production of intracellular reactive oxygen species, reducing mitochondrial membrane potential, and regulating the expression of apoptosis-related genes. The targeting rate of mdGC to tumor tissue is up to 20.71 +/- 1.94% ID g(-1); the tumor growth inhibition rate is as high as 80.44% without external laser sources. In general, mdGC is a potential multifunctional diagnostic and therapy integrated nanoformulation.

gold nanorods mitochondria-mediated apoptosis photoacoustic and fluorescence imaging reactive oxygen species theranostic nanoformulation

SCI ; EI

英语

NI论文

其他

National Natural Science Foundation of China[81922037,11575107,21371115,22003038] ; Shanghai University-Universal Medical Imaging Diagnostic Research Foundation[19H00100] ; Shanghai Biomedical Science and Technology Support Project[19441903600]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000778928700001

WILEY-V C H VERLAG GMBH

20221411918897

Biocompatibility ; Diagnosis ; Disease control ; Fluorescence imaging ; Gold ; Mitochondria ; Molecular imaging ; Nanorods ; Oxygen ; Plasmons ; Tumors

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Biology:461.9 ; Immunology:461.9.1 ; Precious Metals:547.1 ; Imaging Techniques:746 ; Nanotechnology:761 ; Chemical Products Generally:804 ; Atomic and Molecular Physics:931.3 ; Plasma Physics:932.3 ; Solid State Physics:933

MATERIALS SCIENCE

Web of Science

1.Hainan Univ, Sch Pharmaceut Sci, Haikou 570228, Hainan, Peoples R China
2.Shanghai Univ, Sch Environm & Chem Engn, Tumor Precis Targeting Res Ctr, Shanghai 200444, Peoples R China
3.Shanghai Univ, Sch Environm & Chem Engn, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China
4.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Translat Med Collaborat Innovat Ctr, Shenzhen 518055, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 200444, Peoples R China
6.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China
7.Univ Minho, I3Bs Res Inst Biomat Biodegradables & Biomimet, Headquarters European Inst Excellence Tissue Engn, 3Bs Res Grp, P-4805017 Guimaraes, Portugal

Zhang, Junfeng,Yin, Xiaofeng,Li, Chenchen,et al. A Multifunctional Photoacoustic/Fluorescence Dual-Mode-Imaging Gold-Based Theranostic Nanoformulation without External Laser Limitations[J]. ADVANCED MATERIALS,2022,34.

Zhang, Junfeng.,Yin, Xiaofeng.,Li, Chenchen.,Yin, Xuelian.,Xue, Qianghua.,...&Wang, Yanli.(2022).A Multifunctional Photoacoustic/Fluorescence Dual-Mode-Imaging Gold-Based Theranostic Nanoformulation without External Laser Limitations.ADVANCED MATERIALS,34.

Zhang, Junfeng,et al."A Multifunctional Photoacoustic/Fluorescence Dual-Mode-Imaging Gold-Based Theranostic Nanoformulation without External Laser Limitations".ADVANCED MATERIALS 34(2022).