Therapeutic implications of nanodrug and tissue engineering for retinal pigment epithelium-related diseases

Wang, Jiao1; Tao, Zhengyang1; Deng, Hongwei1; Cui, Yubo2,3; Xu, Zhirong4; Lyu, Qinghua1,5; Zhao, Jun2,3

2022-03-01

10.1039/d1nr08337f

Nanoscale   影响因子和分区

2040-3364

2040-3372

The retinal pigment epithelium (RPE), as a single layer of cells that performs multiple functions posteriorly in the eye, is a promising target site for the prevention and treatment of several clinical diseases, including proliferative diabetic retinopathy, age-related macular degeneration, chorionic neovascularization, and retinitis pigmentosa. In recent decades, several nanodrug delivery platforms and tissue-engineered RPE have been widely developed to treat RPE-related diseases. This work summarizes the recent advances in nanoplatforms and tissue engineering scaffolds developed in these fields. The diseases associated with pathological RPE and their common therapy strategies are first introduced. Then, the recent progress made with a variety of drug delivery systems is presented, with an emphasis on the modification strategies of nanomaterials for targeted delivery. Tissue engineering-mediated RPE transplantation for treating these diseases is subsequently described. Finally, the clinical translation challenges in these fields are discussed in depth. This article will offer readers a better understanding of emerging nanotechnology and tissue engineering related to the treatment of RPE-related diseases and could facilitate their widespread use in experiments in vivo and in clinical applications.

SCI ; EI

英语

通讯

Science, Technology and Innovation Commission of Shenzhen Municipality[JCYJ20210324113610029] ; Sanming Project of Medicine in Shenzhen Grant[SZSM201812090]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied

WOS:000774822200001

ROYAL SOC CHEMISTRY

20221612005544

Aldehydes ; Controlled drug delivery ; Disease control ; Diseases ; Eye protection ; Ophthalmology ; Scaffolds (biology) ; Targeted drug delivery

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Organic Compounds:804.1 ; Accidents and Accident Prevention:914.1

Web of Science

1.Shenzhen Univ, Jinan Univ, Shenzhen Eye Hosp, Sch Optometry,Shenzhen Eye Inst, Shenzhen 518000, Peoples R China
2.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Ophthalmol, Shenzhen 518020, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Peoples R China
4.Jinzhou Med Univ, Jinzhou 121000, Liaoning, Peoples R China
5.Shenzhen Univ, Coll Phys & Optoelect Engn, Inst Microscale Optoelect, Shenzhen 518060, Peoples R China

Wang, Jiao,Tao, Zhengyang,Deng, Hongwei,et al. Therapeutic implications of nanodrug and tissue engineering for retinal pigment epithelium-related diseases[J]. Nanoscale,2022,14(15):5657-5677.

Wang, Jiao.,Tao, Zhengyang.,Deng, Hongwei.,Cui, Yubo.,Xu, Zhirong.,...&Zhao, Jun.(2022).Therapeutic implications of nanodrug and tissue engineering for retinal pigment epithelium-related diseases.Nanoscale,14(15),5657-5677.

Wang, Jiao,et al."Therapeutic implications of nanodrug and tissue engineering for retinal pigment epithelium-related diseases".Nanoscale 14.15(2022):5657-5677.