Bi-exponential fitting excluding b=0 data improves the scan-rescan stability of liver IVIM parameter measures and particularly so for the perfusion fraction

Zheng, Cun-Jing1; Xiao, Ben-Heng1; Huang, Hua2; Zhou, Nan3; Yan, Tai-Yu1; Wang, Yi Xiang J.1

2022-03-01

10.21037/qims-2022-02

Quantitative Imaging in Medicine and Surgery   影响因子和分区

2223-4292

2223-4306

["Background: A prerequisite to translating intravoxel incoherent motion (IVIM) imaging into meaningful clinical applications is sufficient scan-rescan reproducibility. This study aims to confirm the hypothesis that IVIM data fitting by not using b=0 images will improve the stability of liver IVIM measurement.","Methods: Healthy volunteers' liver IVIM images were prospectively acquired using a 1.5-T magnet or a 3.0 T with 16 b-values. Repeatability study subjects were scanned twice during the same session, resulted in 35 paired scans for 35 subjects (11 men, mean age: 41.82 yrs, range: 32-60 yrs; 24 women, mean age: 42.67 yrs, range: 20-71 yrs). IVIM analysis was performed with full-fitting and segmented-fitting with a threshold b-value of 60 s/mm(2), and fitting started from b=0 s/mm(2) or from b=2 s/mm(2). Reproducibility study subjects were scanned and then rescanned with an interval of 5-18 days, resulted in 20 paired scans for 11 subjects (4 men, mean age: 26.25 yrs, range: 25-27 yrs; 7 women, mean age: 25.57 yrs, range: 24-27 yrs). IVIM analysis was performed with segmented-fitting with a threshold b-value of 50 s/mm(2), and fitting started from b=0 s/mm(2) or from b=3 s/mm(2).","Results: Fitting without b=0 data generally improved the repeatability and reproducibility for both PF and D-slow, and particularly so for PF. For with b=0 data segmented fitting repeatability, PF had within subject standard deviation of 0.019, bland-Atman 75% agreement limit of -31.52% to 28.35%, and ICC of 0.647, while these values were 0.009, -20.78% to 16.86%, and 0.837 for without b=0 analysis. Though the repeatability and reproducibility for D-fast generally also improved, they remained suboptimal. Measurement stability was better for repeatability than for reproducibility.","Conclusions: Scan-rescan repeatability and reproducibility of liver IVIM parameters can be improved by fitting without b=0 data, which is particularly so for PF."]

Diffusion weighted imaging liver intravoxel incoherent motion (IVIM) reproducibility curve fitting

SCI

英语

其他

Hong Kong GRF[14109218,14112521]

Radiology, Nuclear Medicine & Medical Imaging

Radiology, Nuclear Medicine & Medical Imaging

WOS:000777336000001

AME PUBL CO

Web of Science

1.Chinese Univ Hong Kong, Fac Med, Dept Imaging & Intervent Radiol, Hong Kong, Peoples R China
2.Southern Univ Sci & Technol, Natl Clin Res Ctr Infect Dis, Affiliated Hosp 2, Peoples Hosp Shenzhen 3,Dept Radiol, Shenzhen, Peoples R China
3.Nanjing Univ, Med Sch, Nanjing Drum Tower Hosp, Dept Radiol,Affiliated Hosp, Nanjing, Peoples R China

Zheng, Cun-Jing,Xiao, Ben-Heng,Huang, Hua,et al. Bi-exponential fitting excluding b=0 data improves the scan-rescan stability of liver IVIM parameter measures and particularly so for the perfusion fraction[J]. Quantitative Imaging in Medicine and Surgery,2022.

Zheng, Cun-Jing,Xiao, Ben-Heng,Huang, Hua,Zhou, Nan,Yan, Tai-Yu,&Wang, Yi Xiang J..(2022).Bi-exponential fitting excluding b=0 data improves the scan-rescan stability of liver IVIM parameter measures and particularly so for the perfusion fraction.Quantitative Imaging in Medicine and Surgery.

Zheng, Cun-Jing,et al."Bi-exponential fitting excluding b=0 data improves the scan-rescan stability of liver IVIM parameter measures and particularly so for the perfusion fraction".Quantitative Imaging in Medicine and Surgery (2022).