A Nanoarchitectonic Approach Enables Triple Modal Synergistic Therapies To Enhance Antitumor Effects

Mo, Zhimin1; Li, Qiuting2; Zhao, Kan1; Xu, Qi1; Hu, Han1; Chen, Xu1; Luo, Yuxuan1; Chi, Bin3; Liu, Liping4; Fang, Xiefan5; Liao, Guangfu6; Xu, Zushun1; Wang, Jing3; Yang, Shengli7

2022-03-02

10.1021/acsami.1c20416

ACS Applied Materials & Interfaces   影响因子和分区

1944-8244

1944-8252

Improvement of antitumor effects relies on the development of biocompatible nanomaterials and combination of various therapies to produce synergistic effects and avoid resistance. In this work, we developed GBD-Fe, a nanoformulation that effectively integrated chemotherapy (CT), chemodynamic therapy (CDT), and photothermal therapy (PTT). GBD-Fe used gold nanorods as photothermal agents and encapsulated doxorubicin to amplify Fe3+-guided CDT effects by producing H2O2 and reducing the intracellular glutathione levels. In vitro and in vivo experiments were conducted to demonstrate the enhanced accumulation and antitumor effects of this tripronged therapy under magnetic resonance imaging (MRI) guidance. This tripronged approach of CT/CDT/PTT effectively induced tumor cytotoxicity and inhibited tumor growth in tumor-bearing mice and therefore represents a promising strategy to effectively treat tumors.

tripronged mechanism therapeutic interaction theranostics catalytic activity tumor microenvironment

SCI ; EI

英语

其他

National Natural Science Foundation of China[51573039] ; Key Laboratory of Biological Targeted Therapy, the Ministry of Education[2021swbx019]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000778608900004

AMER CHEMICAL SOC

Web of Science

1.Hubei Univ, Sch Mat Sci & Engn, Hubei Key Lab Polymer Mat, Minist Educ,Key Lab Green Preparat & Applicat Fun, Wuhan 430062, Peoples R China
2.Huazhong Univ Sci & Technol, Liyuan Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430077, Peoples R China
3.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Radiol, Wuhan 430022, Peoples R China
4.Southern Univ Sci & Technol, Dept Hepatobiliary & Pancrease Surg, Shenzhen Peoples Hosp, Clin Med Coll 2,Jinan Univ,Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
5.Charles River Labs Inc, Dept Toxicol, Reno, NV 89511 USA
6.China Univ Geosci, Engn Res Ctr Nanogeomat, Minist Educ, Wuhan 430074, Peoples R China
7.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Canc Ctr, Wuhan 430022, Peoples R China

Mo, Zhimin,Li, Qiuting,Zhao, Kan,et al. A Nanoarchitectonic Approach Enables Triple Modal Synergistic Therapies To Enhance Antitumor Effects[J]. ACS Applied Materials & Interfaces,2022,14(8).

Mo, Zhimin.,Li, Qiuting.,Zhao, Kan.,Xu, Qi.,Hu, Han.,...&Yang, Shengli.(2022).A Nanoarchitectonic Approach Enables Triple Modal Synergistic Therapies To Enhance Antitumor Effects.ACS Applied Materials & Interfaces,14(8).

Mo, Zhimin,et al."A Nanoarchitectonic Approach Enables Triple Modal Synergistic Therapies To Enhance Antitumor Effects".ACS Applied Materials & Interfaces 14.8(2022).